Association between survivin genetic polymorphisms and epidermal growth factor receptor mutation in non-small-cell lung cancer

doi:10.7150/ijms.16875

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/18196

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题名:	Association between survivin genetic polymorphisms and epidermal growth factor receptor mutation in non-small-cell lung cancer
作者:	Liu, T.-C.;Hsieh, M.-J.;Wu, Wu W.-J.;Chou, Y.-E.;Chiang, W.-L.;Yang, S.-F.;Su, Su S.-C.;Tsao, Tsao T.C.-Y.
关键词:	Epidermal growth factor receptor;Genetic variants;Non-small-cell lung carcinoma;Survivin
日期:	2016
上传时间:	2017-08-09T03:25:25Z (UTC)
出版者:	Ivyspring International Publisher
ISSN:	14491907
摘要:	Survivin is an anti-apoptotic protein that is implicated in the regulation of apoptosis and cell cycle in various types of cancers. The current study explored the effect of survivin gene polymorphisms and EGFR mutations in non-small-cell lung carcinoma (NSCLC) patients. A total of 360 participants, including 291 adenocarcinoma lung cancer and 69 squamous cell carcinoma lung cancer patients, were selected for the analysis of three survivin genetic variants (survivin-31, +9194, and +9809) by using real-time PCR genotyping. The results indicated that GC+CC genotypes of survivin-31 were significant association with EGFR mutation in lung adenocarcinoma patients (adjusted odds ratio=3.498, 95% CI = 1.171-10.448; p<0.01). Moreover, The GC+CC genotypes of survivin-31 were associated with EGFR L858R mutation but not in exon 19 in-frame deletions. Furthermore, among patients in exon 19 in-frame deletions, those who have at least one polymorphic G allele of survivin-31 have an increased incidence to develop late-stage when compared with those patients homozygous for C/C (OR, 4.800; 95% CI, 1.305-17.658). In conclusion, our results showed that survivin genetic variants were related to EGFR mutation in lung adenocarcinoma patients and might contribute to pathological development to NSCLC. © Ivyspring International Publisher.
URI:	http://dx.doi.org/10.7150/ijms.16875 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85000605911&doi=10.7150%2fijms.16875&partnerID=40&md5=4ea2f3c4edfec2f192147de2f1523814 https://ir.csmu.edu.tw:8080/ir/handle/310902500/18196
關聯:	International Journal of Medical Sciences 13(12) ,929-935
显示于类别:	[醫學系] 期刊論文

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