中山醫學大學機構典藏 CSMUIR:Item 310902500/18138
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    题名: Association between angiotensin-converting enzyme gene polymorphism and childhood allergic rhinitis in Taiwan
    作者: Ku, M.-S.;Lue, K.-H.;Li, C.;Sun, H.-L.;Chou, M.-C.
    关键词: Genetic polymorphism;Genotype;Peptidyl-dipeptidase A;Perennial allergic rhinitis;Taiwan
    日期: 2006
    上传时间: 2017-08-07T09:14:25Z (UTC)
    ISSN: 16841182
    摘要: Background and Purpose: Angiotensin-converting enzyme (ACE) play a role in inactivating bradykinin and tachykinins. Bradykinin and tachykinins are potent mediators of inflammatory reaction. An insertion/deletion polymorphism of the ACE gene has been shown to be associated with serum ACE levels. We hypothesized that ACE polymorphism might play a role in allergic rhinitis development. Methods: Seventy five children aged 6-13 years with atopic allergic rhinitis and 66 age- and gender-matched healthy children were studied. ACE genotypes were determined by polymerase chain reaction. Serum total immunoglobulin E (IgE) and allergen-specific IgE levels were also measured. Results: The frequencies of the DD and non-DD genotypes, and of the II and non-II genotypes did not differ significantly between healthy children and allergic rhinitis children (chi-squared test, p=1.000 and 0.438, respectively). There was no association of ACE genotype and mean IgE levels in rhinitis children or healthy controls. Conclusion: The results of our study indicate that polymorphism of the ACE gene is unrelated to the development of allergic rhinitis, the duration of allergic rhinitis, serum IgE levels, and allergen-specific IgE in Taiwanese children. ? 2006 Journal of Microbiology, Immunology and Infection.
    URI: http://dx.doi.org/
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-33750591349&partnerID=40&md5=bdb467b1c9251a2b2968791fee6964a2
    https://ir.csmu.edu.tw:8080/ir/handle/310902500/18138
    關聯: Journal of Microbiology, Immunology and Infection 39(4),297-301
    显示于类别:[醫學系] 期刊論文

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