Hylan G-F 20 Has Better Pain Relief and Cost-effectiveness than Sodium Hyaluronate in Treating Early Osteoarthritic Knees in Taiwan

doi:10.1016/S0929-6646(09)60387-9

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/18117

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/18117

Title:	Hylan G-F 20 Has Better Pain Relief and Cost-effectiveness than Sodium Hyaluronate in Treating Early Osteoarthritic Knees in Taiwan
Authors:	Chou, Chou C.-W.;Lue, K.-H.;Lee, H.-S.;Lin, R.-C.;Lu, K.-H.
Keywords:	cost-effectiveness;hyaluronic acid;hylan G-F 20;osteoarthritis
Date:	2009
Issue Date:	2017-08-07T09:13:15Z (UTC)
ISSN:	9296646
Abstract:	Background/Purpose: Intra-articular injection of hyaluronan (hyaluronic acid; HA) products is available to treat early osteoarthritis (OA) of the knee in Taiwan. We tested whether HA products with different molecular weights have significantly different effects on clinical efficacy and cost-effectiveness. Methods: Thirty-seven patients with mild to moderate OA of both knees underwent five weekly intra-articular injections of sodium hyaluronate (Artz?) in one knee and three weekly intra-articular injections of chemically cross-linked Hylan G-F 20 (Synvisc?) in the other. Visual analog scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Lequesne's index, and Hospital for Special Surgery (HSS) knee scores were compared initially and at the last injection, and at 8, 12, 16, 20, and 26 weeks after the first injection. Results: VAS, WOMAC, WOMAC-A1 (pain when walking on a flat surface) scores before week 16, HSS scores before week 12, and Lequesne's index scores except at week 26 all showed that HA significantly improved the scores time-dependently. In VAS scores, Synvisc? showed better improvement before week 20, while this effect appeared at week 12 for the WOMAC-A1 scores. The incremental cost-effectiveness ratio of the Taiwan National Health Insurance Program, of the patient, and both of these was lower for Synvisc?, which also reduced the number of additional hospital visits for injections by two. Conclusion: Synvisc? possesses better symptom-modifying ability and cost-utility in treating early OA of the knee in Taiwan. ? 2009 Formosan Medical Association & Elsevier.
URI:	http://dx.doi.org/10.1016/S0929-6646(09)60387-9 https://www.scopus.com/inward/record.uri?eid=2-s2.0-70349277440&doi=10.1016%2fS0929-6646%2809%2960387-9&partnerID=40&md5=ff632f95660daa047a2cafe2eb9edbf5 https://ir.csmu.edu.tw:8080/ir/handle/310902500/18117
Relation:	Journal of the Formosan Medical Association 108(8),663-672
Appears in Collections:	[醫學系] 期刊論文

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