中山醫學大學機構典藏 CSMUIR:Item 310902500/18061
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    题名: Extracts from cigarette smoke induce DNA damage and cell adhesion molecule expression through different pathways
    作者: Chen, H.-W.;Chien, M.-L.;Chaung, Y.-H.;Lii, C.-K.;Wang, T.-S.
    日期: 2004
    上传时间: 2017-08-01T08:18:01Z (UTC)
    ISSN: 00092797
    摘要: Cigarette smoke is a major risk factor for human diseases, such as lung cancer and atherosclerosis. The present study was undertaken to investigate the effect of non-fractionated water-soluble cigarette smoke extract (NFWS CSE) on DNA damage and cellular adhesion molecule expression in human umbilical vein endothelial cells (HUVECs). DNA damage and the surface expression of intercellular adhesion molecule-1 (ICAM-1) and E-selectin were determined by the use of the comet assay and flow cytometry, respectively. NFWS CSE-induced DNA damage in a dose-dependent manner during a 2 h exposure. Pretreatment with ascorbic acid or α-tocopherol completely inhibited the NFWS CSE-induced DNA damage. NFWS CSE exposure also up-regulated the surface expression of ICAM-1 and E-selectin in HUVECs. Pretreatment with ascorbic acid or α-tocopherol had no effect on NFWS CSE-induced E-selectin and ICAM-1 expression. In contrast, the non-antioxidant metal chelator 1,10-phenanthroline partially suppressed the surface expression of ICAM-1 and E-selectin. These results suggest that NFWS CSE exposure induces both DNA damage and the surface expression of adhesion molecules in HUVECs. However, the molecular mechanism of these effects may be through different pathways: reactive oxygen species are involved in NFWS CSE-induced DNA damage but have little relation to NFWS CSE-induced E-selectin and ICAM-1 expression. © 2004 Elsevier Ireland Ltd. All rights reserved.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/18061
    http://dx.doi.org/10.1016/j.cbi.2004.09.014
    關聯: Chemico-Biological Interactions 150, 233-241
    显示于类别:[生物醫學科學學系暨碩士班] 期刊論文

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