α-Mangostin induces mitochondrial dependent apoptosis in human hepatoma SK-Hep-1 cells through inhibition of p38 MAPK pathway

doi:10.1007/s10495-013-0888-5

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题名:	α-Mangostin induces mitochondrial dependent apoptosis in human hepatoma SK-Hep-1 cells through inhibition of p38 MAPK pathway
作者:	Hsieh, Shu-Ching;Huang, Min-Hsien;Cheng, Chun-Wen;Hung, Jyun-Hao;Yang, Shun-Fa;Hsieh, Yi-Hsien
贡献者:	中山醫大
关键词:	α-Mangostin;Apoptosis;Caspase;Human hepatocellular carcinoma;Mitochondrial;p38 MAPK
日期:	2013
上传时间:	2017-07-11T09:12:36Z (UTC)
出版者:	Apoptosis
ISSN:	1360-8185
摘要:	Abstract α-Mangostin is a dietary xanthone that has been shown to have anti-cancer and anti-proliferative properties in various types of human cancer cells. This study investigates the molecular mechanism of the apoptosis-inducing effects of α-mangostin on human hepatocellular carcinoma (HCC) cells. We observed that α-mangostin reduces the viability of HCC cells in a dose- and time-dependent manner. α-Mangostin mediated apoptosis of SK-Hep-1 cells is accompanied by nuclear chromatin condensation and cell cycle arrest in the sub-G1 phases as well as phosphatidylserine exposure. Furthermore, α-mangostin triggered the mitochondrial caspase apoptotic pathway, as indicated by the loss of mitochondrial membrane potential, the release of cytochrome c from mitochondria, and the regulation of B cell lymphoma 2 family member expression. Moreover, α-mangostin inhibited a sustained activation of p38 mitogen-activated protein kinase (MAPK) phosphorylation, and treatment with a p38 MAPK inhibitor enhanced α-mangostin-induced caspase activation and apoptosis in SK-Hep-1 cells. In vivo xenograft mice experiments revealed that α-mangostin significantly reduced tumor growth and weight in mice inoculated with SK-Hep-1 cells. These findings demonstrate that α-mangostin induces mitochondria-mediated apoptosis through inactivation of the p38 MAPK signaling pathway and that α-mangostin inhibits the in vivo tumor growth of SK-Hep-1 xenograft mice.
URI:	http://dx.doi.org/10.1007/s10495-013-0888-5 https://ir.csmu.edu.tw:8080/ir/handle/310902500/17964
關聯:	Apoptosis. 2013 Dec;18(12):1548-60.
显示于类别:	[醫學系] 期刊論文

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