中山醫學大學機構典藏 CSMUIR:Item 310902500/17961
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    题名: Licochalcone A inhibits the migration and invasion of human lung cancer cells via inactivation of the Akt signaling pathway with downregulation of MMP-1/-3 expression
    作者: Huang, Hung-Che
    Tsai, Lo-Lin
    Tsai, Jen-Pi
    Hsieh, Shu-Ching
    Yang, Shun-Fa
    Hsueh, Jung-Tsung
    Hsieh, Yi-Hsien
    贡献者: 中山醫大
    关键词: Lung cancer cells;LicA;Migration;Invasion;MMP-1;MMP-3;Sp1
    日期: 2014
    上传时间: 2017-07-11T09:04:13Z (UTC)
    出版者: Tumor Biology
    ISSN: 1010-4283
    摘要: Abstract
    Licochalcone A (LicA), a major phenolic constituent of Glycyrrhiza inflata, has been reported to exhibit anti-tumor, anti-inflammatory, and anti-metastatic properties in various cancer cells and animal models. The aim of this study was to determine the anti-tumor effects of LicA on lung cancer cells. The results indicated that LicA exhibited effective inhibition of cell migration and invasion of A549 and H460 cells under non-cytotoxic concentrations. Furthermore, LicA was also found to significantly inhibit the proteins and messenger RNA (mRNA) expression of MMP-1 and MMP-3 in A549 cells. Moreover, treatment of A549 cells with LicA-inhibited activation of the phosphorylation of Akt and inhibition of Akt by LY294002 (PI3K inhibitor) or transfection with the constitutive active-Akt (CA-Akt) expression vector significantly abolished the LicA-inhibited migration and invasion through activation of the Akt pathway. Further mechanistic studies revealed that LicA inhibits Akt signaling pathways and downstream transcription factors Sp1 expression. These findings imply a critical role for Akt inhibition in the LicA-inhibited migration and invasion of lung cancer cells. Thus, LicA might be used as an anti-invasive agent in the treatment of lung cancer.
    URI: http://dx.doi.org/10.1007/s13277-014-2519-3
    https://ir.csmu.edu.tw:8080/ir/handle/310902500/17961
    關聯: Tumor Biology December 2014, Volume 35, Issue 12, pp 12139–12149
    显示于类别:[醫學系] 期刊論文

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