Evaluation of Xanthine Oxidase Inhibitory Potential and In vivo Hypouricemic Activity of Dimocarpus longan Lour. Extracts

doi:10.4103/0973-1296.182176

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/17883

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题名:	Evaluation of Xanthine Oxidase Inhibitory Potential and In vivo Hypouricemic Activity of Dimocarpus longan Lour. Extracts
作者:	Sheu, Shi-Yuan Fu, Yuan-Tsung Huang, Wen-Dar Chen, Yung-Ann Lei, Yi-Chih Yao, Chun-Hsu Hsu, Feng-Lin Kuo, Tzong-Fu
贡献者:	中山醫大
关键词:	Dimocarpus longan Lour, hypouricemic effect, xanthine oxidase inhibition
日期:	2016-05
上传时间:	2017-06-30T08:09:37Z (UTC)
出版者:	Pharmacogn Mag
ISSN:	0973-1296
摘要:	Abstract Background: Longan is a fruit tree known to contain many phenolic components, which are capable of protecting people from oxidative damage through an anti-inflammatory mechanism. It may be also worthwhile to study the effect on lowering uric acid activity. Materials and Methods: This study investigates the lowering of uric acid using longan extracts, including flowers, pericarps, seeds, leaves, and twigs, on potassium-oxonate-induced hyperuricemia mice and its inhibitory actions against xanthine oxidase (XO) activities. Results: The findings revealed that ethyl acetate fraction of longan extracts exhibited strong XO-inhibitory activity, and the flower extracts (IC50 = 115.8 μg/mL) revealed more potent XO-inhibitory activity to those of pericarps (118.9 μg/mL), twigs (125.3 μg/mL), seeds (262.5 μg/mL), and leaves (331.1 μg/mL) in vitro. In addition, different dosages of longan extract (50–100 mg/kg) were administered to hyperuricemic mice. The lowering effect of longan extracts on uric acid at 75 mg/kg markedly reduced plasma uric acid levels in decreasing order: Flowers (80%) > seeds (72%) > pericarps (64%) > twigs (59%) > leaves (41%), compared with allopurinol (89%). Finally, 10 isolated phytochemicals from longan flowers were then examined in vitro. The results indicated that proanthocyanidin A2 and acetonylgeraniin A significantly inhibited XO activity in vitro. This is the first report providing new insights into the urate-reducing effect of phenolic dimer and hydrolyzable tannin, which can be developed to potential hypouricemic agents.
URI:	http://dx.doi.org/10.4103/0973-1296.182176 https://ir.csmu.edu.tw:8080/ir/handle/310902500/17883
關聯:	Pharmacogn Mag. 2016 May; 12(Suppl 2): S206–S212.
显示于类别:	[醫學系] 期刊論文

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