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| Title: | Evaluation of Xanthine Oxidase Inhibitory Potential and In vivo Hypouricemic Activity of Dimocarpus longan Lour. Extracts |
| Authors: | Sheu, Shi-Yuan
Fu, Yuan-Tsung
Huang, Wen-Dar
Chen, Yung-Ann
Lei, Yi-Chih
Yao, Chun-Hsu
Hsu, Feng-Lin
Kuo, Tzong-Fu |
| Contributors: | 中山醫大 |
| Keywords: | Dimocarpus longan Lour, hypouricemic effect, xanthine oxidase inhibition |
| Date: | 2016-05 |
| Issue Date: | 2017-06-30T08:09:37Z (UTC)
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| Publisher: | Pharmacogn Mag |
| ISSN: | 0973-1296 |
| Abstract: | Abstract
Background:
Longan is a fruit tree known to contain many phenolic components, which are capable of protecting people from oxidative damage through an anti-inflammatory mechanism. It may be also worthwhile to study the effect on lowering uric acid activity.
Materials and Methods:
This study investigates the lowering of uric acid using longan extracts, including flowers, pericarps, seeds, leaves, and twigs, on potassium-oxonate-induced hyperuricemia mice and its inhibitory actions against xanthine oxidase (XO) activities.
Results:
The findings revealed that ethyl acetate fraction of longan extracts exhibited strong XO-inhibitory activity, and the flower extracts (IC50 = 115.8 μg/mL) revealed more potent XO-inhibitory activity to those of pericarps (118.9 μg/mL), twigs (125.3 μg/mL), seeds (262.5 μg/mL), and leaves (331.1 μg/mL) in vitro. In addition, different dosages of longan extract (50–100 mg/kg) were administered to hyperuricemic mice. The lowering effect of longan extracts on uric acid at 75 mg/kg markedly reduced plasma uric acid levels in decreasing order: Flowers (80%) > seeds (72%) > pericarps (64%) > twigs (59%) > leaves (41%), compared with allopurinol (89%). Finally, 10 isolated phytochemicals from longan flowers were then examined in vitro. The results indicated that proanthocyanidin A2 and acetonylgeraniin A significantly inhibited XO activity in vitro. This is the first report providing new insights into the urate-reducing effect of phenolic dimer and hydrolyzable tannin, which can be developed to potential hypouricemic agents. |
| URI: | http://dx.doi.org/10.4103/0973-1296.182176
https://ir.csmu.edu.tw:8080/ir/handle/310902500/17883 |
| Relation: | Pharmacogn Mag. 2016 May; 12(Suppl 2): S206–S212. |
| Appears in Collections: | [醫學系] 期刊論文
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