Expression of Bak and Bak/Mcl-1 ratio can predictphotodynamic therapy outcome for oral verrucoushyperplasia and leukoplakia

doi:10.1111/jop.12007

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/17864

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题名:	Expression of Bak and Bak/Mcl-1 ratio can predictphotodynamic therapy outcome for oral verrucoushyperplasia and leukoplakia
作者:	Yu, Chuan-Hang Chen, Hsin-Ming Lin, Hung-Pin Chiang, Chun-Pin
贡献者:	中山醫學大學
关键词:	5-aminolevulinic acid;clinical outcome;immunohis-tochemistry;oral leukoplakia;oral verrucous hyperplasia;photo-dynamic therapy
日期:	2012
上传时间:	2017-06-29T08:27:59Z (UTC)
ISSN:	0904-2512
摘要:	BACKGROUND: Our previous studies showed that top-ical 5-aminolevulinic acid-mediated photodynamic ther-apy (ALA-PDT) is very effective for oral verrucoushyperplasia (OVH) and relatively less effective for oralleukoplakia (OL) lesions. Nevertheless, there has been noreport on the association of the expression of apoptosis-related proteins in OVH and OL biopsy tissues prior toPDT with PDT treatment outcomes.METHODS: This study used immunohistochemistry toevaluate whether the expression of Bak, Mcl-1, caspase-3,caspase-8, caspase-9, p53, p21, or PCNA protein in biopsyspecimens of OVH and OL lesions could be used to predictthe clinical outcomes of 18 OVH and 40 OL lesions treatedwith topical ALA-PDT. The marker labeling score (LS) wasdefined as labeling index (positive cells/total cells) multi-plied by staining intensity. The lesions after ALA-PDTtreatment were divided into complete response (CR)group and partial or no response (PR/NR) group.RESULTS: The mean Bak LS and the mean Bak/Mcl-1 LSratio were significantly higher in the CR group than in thePR/NR group. However, there was no significant differencein the Mcl-1, caspase-3, caspase-8, caspase-9, p53, p21, orPCNA protein LS between the CR and PR/NR groups.CONCLUSION: We conclude that the Bak LS or Bak/Mcl-1 LS ratio may be a useful biomarker to predict theclinical outcomes of OVH and OL lesions treated withtopical ALA-PDT. Pre-PDT epithelial cell levels of Mcl-1,caspase-3, caspase-8, caspase-9, p53, p21, and PCNA maynot have a significant influence on the clinical outcome ofOVH and OL lesions treated with topical ALA-PDT.
URI:	http://dx.doi.org/10.1111/jop.12007 https://ir.csmu.edu.tw:8080/ir/handle/310902500/17864
關聯:	J Oral Pathol Med (2013) 42: 257--262
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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