Euphorbia formosana root extract induces apoptosis by caspase-dependent cell death via Fas and mitochondrial pathway in THP-1 human leukemic cells

doi:10.3390/molecules18021949

中山醫學大學機構典藏 CSMUIR > 健康管理學院 > 醫學應用化學系暨碩士班 > 期刊論文 > Item 310902500/17837

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/17837

Title:	Euphorbia formosana root extract induces apoptosis by caspase-dependent cell death via Fas and mitochondrial pathway in THP-1 human leukemic cells
Authors:	Hsieh, Yi-Jen Chang, Chih-Jui Wan, Chin-Feng Chen, Chin-Piao Chiu, Yi-Han Leu, Yann-Lii Peng, Kou-Cheng
Contributors:	中山醫大
Keywords:	Euphorbia formosana;apoptosis;mitochondrial pathway;Fas pathway
Date:	2013
Issue Date:	2017-06-27T09:28:28Z (UTC)
Publisher:	Molecules
ISSN:	1420-3049
Abstract:	Abstract Acute myeloid leukemia (AML), a very rare type of cancer, generally affects patients over 50 years old. While clinical drugs to treat advanced stages of AML exist, the disease becomes increasingly resistant to therapies. Euphorbia formosana Hayata (EF) is a native Taiwanese medicinal plant used to treat rheumatism, liver cirrhosis, herpes zoster, scabies, and photoaging, along with tumor suppression. However, the mechanisms by which it suppresses tumors have not been explored. Here, we provide molecular evidence that a hot-water extract of Euphorbia formosana (EFW) selectively inhibited the growth of human leukemic cancer cells more than other solid human cancer cell lines. Most importantly, the plant extract had limited toxicity toward healthy peripheral blood mononuclear cells (PBMCs). After THP-1 leukemic cells were treated with 50-100 µg/mL EFW for one day, the S phase DNA content of the cells increased, while treatment with 200-400 µg/mL caused the cells to accumulate in the G0/G1 phase. Notably, EFW did not affect A-549 lung cancer cells. The effectiveness of EFW against THP-1 cells may be through caspase-dependent apoptosis in leukemic cells, which is mediated through the Fas and mitochondrial pathways. The potent antileukemic activity of EFW in vitro warrants further investigation of this plant to treat leukemias and other malignancies.
URI:	https://www.doi.org/10.3390/molecules18021949 https://ir.csmu.edu.tw:8080/ir/handle/310902500/17837
Relation:	Molecules. 2013 Feb 1;18(2):1949-62.
Appears in Collections:	[醫學應用化學系暨碩士班] 期刊論文

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