Beneficial effects of noni (Morinda citrifolia L.) juice on livers of high-fat dietary hamsters

doi:10.1016/j.foodchem.2013.02.035

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/17824

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/17824

Title:	Beneficial effects of noni (Morinda citrifolia L.) juice on livers of high-fat dietary hamsters
Authors:	Lin, Yi-Ling Chang, Yuan-Yen Yang, Deng-Jye Tzang, Bor-Show Chen, Yi-Chen
Contributors:	醫學研究所
Keywords:	Anti-inflammatory response;Antioxidant capacity;Nonalcoholic fatty liver;Noni juice;Polyphenol
Date:	2013-09
Issue Date:	2017-06-27T08:26:17Z (UTC)
Publisher:	Food Chemistry
ISSN:	0308-8146
Abstract:	Abstract Polyphenols in noni juice (NJ) are mainly composed of phenolic acids, mainly gentisic, p-hydroxybenoic, and chlorogenic acids. To investigate the beneficial effects of NJ on the liver, hamsters were fed with two diets, normal-fat and high-fat diets. Furthermore, high-fat dietary hamsters were received distilled water, and 3, 6, and 9 mL NJ/kg BW, respectively. After a 6-week feeding period, the increased (p < 0.05) sizes of liver and visceral fat in high-fat dietary hamsters compared to the control hamsters were ameliorated (p < 0.05) by NJ supplementation. NJ also decreased (p < 0.05) serum/liver lipids but enhanced (p < 0.05) daily faecal lipid/bile acid outputs in the high-fat dietary hamsters. High-fat dietary hamsters supplemented with NJ had higher (p < 0.05) liver antioxidant capacities but lowered (p < 0.05) liver iNOS, COX-2, TNF-α, and IL-1β expressions, gelatinolytic levels of MMP9, and serum ALT values compared to those without NJ. Hence, NJ protects liver against a high-fat dietary habit via regulations of antioxidative and anti-inflammatory responses. Highlights ► Gentisic, p-hydroxybenoic, and chlorogenic acids are major phenolic acid compounds in noni juice (NJ). ► NJ decreases serum and liver lipids of hamsters in a high-fat diet group. ► NJ enhances liver antioxidative capacities in a high-fat diet. ► NJ alleviates liver iNOS, COX-2, TNF-α, and IL-1β expressions and gelatinolytic levels of MMP-9 in a high-fat diet. ► NJ protects liver against oxidative stress and inflammatory responses in a high-fat diet.
URI:	https://doi.org/10.1016/j.foodchem.2013.02.035 https://ir.csmu.edu.tw:8080/ir/handle/310902500/17824
Relation:	Food Chemistry Volume 140, Issues 1–2, 1–15 September 2013, Pages 31-38
Appears in Collections:	[醫學系] 期刊論文

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	297	View/Open

View Licence

Loading...