Taurine ameliorates alcoholic steatohepatitis via enhancing self-antioxidant capacity and alcohol metabolism

doi:10.1016/j.foodres.2011.08.004

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题名:	Taurine ameliorates alcoholic steatohepatitis via enhancing self-antioxidant capacity and alcohol metabolism
作者:	Fang, Yi-Jen Chou, Chung-Hsi Chen, Ming-Feng Chen, Yi-Chen Chiu, Chih-Hsien Chang, Yuan-Yen Lin, Hui-Wen
贡献者:	醫學研究所
关键词:	Alcoholic steatohepatitis;Antioxidant capacity;Alcohol metabolism;Liver lipids;Liver damage
日期:	2011-11
上传时间:	2017-06-27T08:17:09Z (UTC)
出版者:	Food Research International
ISSN:	0963-9969
摘要:	Abstract Chronic alcohol consumption or alcohol abuse is the main cause of alcoholic steatohepatitis or further cirrhosis. This study was to exam if the antioxidant capacity and alcohol metabolism in livers of chronic alcohol-fed rats were improved by supplementing taurine (Tau). Rats were randomly divided into four groups with five times per week of treatment: 1) isocaloric solution; 2) 3 g alcohol/kg BW/day; 3) 3 g alcohol/kg BW/day + 1 g taurine (Tau)/kg BW/day; and 4) 3 g alcohol/kg BW/day + 2 g Tau/kg BW/day. A 6-week alcohol consumption resulted in lower (p < 0.05) body weight gain and self-antioxidant capacities, as well as increased (p < 0.05) liver size, serum/hepatic lipids, and AST and ALT values. However, alcohol-fed rats co-treated with Tau have decreased (p < 0.05) liver lipid levels via increasing fecal lipid output and cholesterol metabolism. Besides, co-treatment of Tau also enhanced (p < 0.05) self-antioxidant capacities and alcohol metabolism in livers via enhancing GSH contents, CAT, GSH-Px, ADH, and ALDH activities, but decreasing MDA contents. In a histological examination of rat liver, microvesicular steatosis and necrotic cells were observed in alcohol-fed rats without Tau while largely suppressed microvesicular steatosis and no necrotic cells were observed in alcohol-fed rat supplemented with Tau. Therefore, Tau could be an effective hepatoprotective agent against alcohol-induced damage via enhancing self-antioxidant capacity and alcohol metabolism. Highlights ► Taurine increases liver self antioxidant capacities in chronic alcohol consumption. ► Taurine accelerates alcohol metabolism in chronic alcohol consumption. ► Taurine protects liver damage from chronic alcohol consumption. Abbreviations ADHalcohol dehydrogenaseALDHaldehyde dehydrogenaseALTalanine aminotransferaseASTaspartate aminotransferaseCATcatalaseCYP2E1cytochrome P450, subfamily e, polypepetide 1GSHglutathioneGSH-Pxglutathione peroxidaseMDAmalondialdehydeTautaurineTCtotal cholesterolTGtotal triglyceride
URI:	https://doi.org/10.1016/j.foodres.2011.08.004 https://ir.csmu.edu.tw:8080/ir/handle/310902500/17822
關聯:	Food Research International Volume 44, Issue 9, November 2011, Pages 3105-3110
显示于类别:	[醫學系] 期刊論文

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