Elevated risk of hypertension induced by arsenic exposure in Taiwanese rural residents: possible effects of manganese superoxide dismutase (MnSOD) and 8-oxoguanine DNA glycosylase (OGG1) genes

doi:10.1007/s00204-011-0797-8

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/17812

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Title:	Elevated risk of hypertension induced by arsenic exposure in Taiwanese rural residents: possible effects of manganese superoxide dismutase (MnSOD) and 8-oxoguanine DNA glycosylase (OGG1) genes
Authors:	Chen, Shiuan-Chih Chen, Chun-Chieh Kuo, Chung-Yih Huang, Chun-Huang Lin, Chin-Hsiu Lu, Zi-Yun Chen, Yi-Yu Lee, Hong-Shen Wong, Ruey-Hong
Contributors:	醫學研究所
Keywords:	Hypertension;Arsenic;Lead;MnSOD gene;OGG1 gene
Date:	2011-12-23
Issue Date:	2017-06-27T07:34:41Z (UTC)
Publisher:	Archives of Toxicology
ISSN:	0340-5761
Abstract:	Abstract Heavy metals, including arsenic and lead, may lead to cellular oxidative damage that is linked to hypertension. Manganese superoxide dismutase (MnSOD) is a scavenger of reactive oxygen species, and 8-oxoguanine DNA glycosylase (OGG1) is the major glycosylase that repairs DNA lesions. Interestingly, whether there is an elevated risk of hypertension with arsenic or lead exposure in individuals with genetic variations in MnSOD or OGG1 has not yet been investigated. Questionnaires were administered to 240 Taiwanese rural residents. Blood pressure and biochemical indicators were assessed in each subject. Urinary levels of arsenic and lead were measured with atomic absorption spectrometry; and MnSOD and OGG1 genotypes were identified via polymerase chain reaction. There was a dose–response relationship between urinary arsenic levels and risk of hypertension (P = 0.021, test for trend). However, there was no association between urinary lead levels and hypertension risk. Individuals with high urinary arsenic levels and the MnSOD Val–Ala/Ala–Ala genotypes had a greater risk of hypertension than those with low urinary arsenic levels and the MnSOD Val–Val genotype (odds ratio [OR] = 4.2, 95% confidence interval [CI] = 1.7–10.3). Subjects with a high urinary arsenic level and the OGG1 Cys–Cys genotype also had a greater risk of hypertension than those with a low urinary arsenic level and the OGG1 Ser–Ser/Ser–Cys genotypes (OR = 3.4, 95% CI = 1.1–10.7). Thus, both MnSOD and OGG1 genotypes may be prone to an increased risk of hypertension associated with arsenic exposure.
URI:	https://www.doi.org/10.1007/s00204-011-0797-8 https://ir.csmu.edu.tw:8080/ir/handle/310902500/17812
Relation:	Archives of Toxicology June 2012, Volume 86, Issue 6, pp 869–878
Appears in Collections:	[醫學系] 期刊論文

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