Tissue-engineered fascia from vaginal fibroblasts for patients needing reconstructive pelvic surgery

doi:10.1007/s00192-010-1168-3

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/17796

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题名:	Tissue-engineered fascia from vaginal fibroblasts for patients needing reconstructive pelvic surgery
作者:	Hung, Man-Jung Wen, Mei-Chin Hung, Chia-Nung Ho, Esther Shih-Chu Chen, Gin-Den Cheng, Yang Vivian
贡献者:	醫學研究所
关键词:	Human vaginal fibroblasts;Pelvic organ prolapse;Reconstructive pelvic surgery;Regenerative medicine;Synthetic mesh;Tissue-engineering
日期:	2010-05-18
上传时间:	2017-06-26T08:55:48Z (UTC)
出版者:	International Urogynecology Journal
ISSN:	0937-3462
摘要:	Abstract Introduction and hypothesis Mesh-augmented reconstructive surgery for pelvic organ prolapse (POP) does not meet clinical expectations. A tissue-engineered fascia equivalent needs to be developed. Methods Human vaginal fibroblasts (HVFs) from 10 patients were characterized in vitro. Eligible HVFs and a biodegradable scaffold were used to fabricate a fascia equivalent, which was then transplanted in vivo. Results The cultured HVFs were divided into high (n = 6) or low (n = 4) collagen I/III ratio groups. Cells of the high-ratio group exhibited significantly higher proliferation potential than those of the low-ratio group (P < 0.05). A fascia equivalent was made with HVFs of the high-ratio group. In the subsequent animal study, a well-organized neo-fascia formation containing HVFs could be traced up to 12 weeks after transplantation. Conclusions Our results suggest that a tissue-engineered fascia could be developed from HVFs in vitro and in vivo, which might be an effective treatment for POP in the future.
URI:	https://www.doi.org/10.1007/s00192-010-1168-3 https://ir.csmu.edu.tw:8080/ir/handle/310902500/17796
關聯:	International Urogynecology Journal September 2010, Volume 21, Issue 9, pp 1085–1093
显示于类别:	[醫學系] 期刊論文

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