Risk factors that affect the treatment of interstitial cystitis using intravesical therapy with a dimethyl sulfoxide cocktail

doi:10.1007/s00192-012-1699-x

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/17794

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题名:	Risk factors that affect the treatment of interstitial cystitis using intravesical therapy with a dimethyl sulfoxide cocktail
作者:	Hung, Man-Jung Chen, Yi-Ting Shen, Pao-Sheng Hsu, Shih-Tien ChenGin-Den Ho, Esther Shih-Chu
贡献者:	醫學研究所
日期:	2012-11
上传时间:	2017-06-26T08:49:40Z (UTC)
出版者:	International Urogynecology Journal
ISSN:	0937-3462
摘要:	Abstract Introduction and hypothesis Dimethyl sulfoxide (DMSO) bladder instillation is a standard therapy for interstitial cystitis (IC); however, there are varying degrees of success. We hypothesize that first-line intravesical therapy with a DMSO cocktail will optimize treatment outcome. Methods Ninety women with newly diagnosed IC were enrolled consecutively for the treatment. The IC symptom and problem index was used as an outcome measure. Results Six (6.7%) patients dropped out of the treatment due to intolerable bladder irritation. Fifty-five (65.5%) of the remaining 84 patients, who completed the treatment, experienced ≧50% symptomatic improvement. After a regression analysis, three clinical variables were found to affect treatment adversely, i.e., the presence of advanced cystoscopic glomerulations, microscopic hematuria, and urodynamic detrusor underactivity, respectively. Conclusions Our results suggest bladder instillation with a DMSO cocktail may well be considered as first-line therapy for IC patients. However, there exists a subgroup of nonresponders who may have severe disease.
URI:	https://www.doi.org/10.1007/s00192-012-1699-x https://ir.csmu.edu.tw:8080/ir/handle/310902500/17794
關聯:	International Urogynecology Journal November 2012, Volume 23, Issue 11, pp 1533–1539
显示于类别:	[醫學系] 期刊論文

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