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Please use this identifier to cite or link to this item:
https://ir.csmu.edu.tw:8080/ir/handle/310902500/17709
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| Title: | Role of Pigment Epithelium-Derived Factor in Stem/Progenitor Cell-Associated Neovascularization |
| Authors: | Liu, Jung-Tung
Chen, Yuh-Lien
Chen, Wen-Chi
Chen, Huey-Yi
Lin, Yi-Wen
Wang, Shu-Huei
Man, Kee-Ming
Wan, Hui-Min
Yin, Wei-Hsian
Liu, Po-Len
Chen, Yung-Hsiang |
| Contributors: | 醫學研究所 |
| Date: | 2012 |
| Issue Date: | 2017-05-31T09:16:23Z (UTC)
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| ISSN: | 1110-7243 |
| Abstract: | Pigment epithelium-derived factor (PEDF) was first identified in retinal pigment epithelium cells. It is an endogenously produced protein that is widely expressed throughout the human body such as in the eyes, liver, heart, and adipose tissue; it exhibits multiple and varied biological activities. PEDF is a multifunctional protein with antiangiogenic, antitumorigenic, antioxidant, anti-inflammatory, antithrombotic, neurotrophic, and neuroprotective properties. More recently, PEDF has been shown to be the most potent inhibitor of stem/progenitor cell-associated neovascularization. Neovascularization is a complex process regulated by a large, interacting network of molecules from stem/progenitor cells. PEDF is also involved in the pathogenesis of angiogenic eye disease, tumor growth, and cardiovascular disease. Novel antiangiogenic agents with tolerable side effects are desired for the treatment of patients with various diseases. Here, we review the value of PEDF as an important endogenous antiangiogenic molecule; we focus on the recently identified role of PEDF as a possible new target molecule to influence stem/progenitor cell-related neovascularization. |
| URI: | http://dx.doi.org/10.1155/2012/871272
https://ir.csmu.edu.tw:8080/ir/handle/310902500/17709 |
| Relation: | Journal of Biomedicine and BiotechnologyVolume 2012 (2012), Article ID 871272, 10 pages |
| Appears in Collections: | [醫學系] 期刊論文
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