Adjunctive Treatment with Rhodiola Crenulata in Patients with Chronic Obstructive Pulmonary Disease – A Randomized Placebo Controlled Double Blind Clinical Trial

doi:10.1371/journal.pone.0128142

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題名:	Adjunctive Treatment with Rhodiola Crenulata in Patients with Chronic Obstructive Pulmonary Disease – A Randomized Placebo Controlled Double Blind Clinical Trial
作者:	Chuang, Ming-Lung Wu, Tzu-Chin Wang, Yau-Tung Wang, Yau-Chen Thomas, C.-Y.Tsao Wei, James Cheng-Chung Chen, Chia-Yin Lin, I-Feng
貢獻者:	醫學研究所
日期:	2015-06-22
上傳時間:	2017-05-31T09:08:58Z (UTC)
ISSN:	1932-6203
摘要:	Chronic obstructive pulmonary disease (COPD) is a low grade systemic inflammatory disease characterized by dyspnea and exercise intolerance even under standard therapy. Rhodiola crenulata (RC) has been shown to exert anti-inflammatory effects and to enhance exercise endurance, thereby having the potential to treat COPD. In this 12-week, randomized, double-blind, placebo-controlled clinical trial, 57 patients with stable moderate-to-severe COPD aged 70±8.8 years were given RC (250 mg twice/day) (n=38) or a placebo (250 mg twice/day) (n=19) in addition to their standard regimen. There were no significant differences in anthropometrics, quality of life, lung function, six-minute walk and incremental exercise tests between the two groups at enrollment. Over the 12 weeks, RC was well tolerated, significantly reduced triceps skin thickness (Δ=-1 mm, p=.04), change of FEV1 (4.5%, p=.03), and improved workload (Δ=10%, p=.01); although there were no significant differences in these factors between the two groups. However, there were significant between-group differences in tidal volume and ventilation-CO2-output ratio at peak exercise (both p=.05), which were significantly related to peak work rate (both p<.0001). RC tended to protect against acute exacerbation of COPD (p=.1) but not other measurements. RC did not improve the six-minute walk test distance but significantly improved tidal breathing and ventilation efficiency, most likely through improvements in work rate. Further studies with a larger patient population are needed in order to confirm these findings.
URI:	http://dx.doi.org/10.1371/journal.pone.0128142 https://ir.csmu.edu.tw:8080/ir/handle/310902500/17707
關聯:	PLoS One. 2015; 10(6): e0128142.
顯示於類別:	[醫學研究所] 期刊論文

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