Regulator of G protein signaling 2 (Rgs2) regulates neural crest development through Pparδ-Sox10 cascade

doi:10.1016/j.bbamcr.2016.12.013

中山醫學大學機構典藏 CSMUIR > 健康管理學院 > 醫學應用化學系暨碩士班 > 期刊論文 > Item 310902500/16943

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题名:	Regulator of G protein signaling 2 (Rgs2) regulates neural crest development through Pparδ-Sox10 cascade
作者:	Lin, S.-J. Chiang, M.-C. Shih, H.-Y. Hsu, L.-S. Yeh, T.-H. Huang, Y.-C. Lin, C.-Y. Cheng, Y.-C.
贡献者:	生化暨生物科技研究所
关键词:	Neural crest;Pparδ;Rgs2;Sox10;Zebrafish
日期:	2017-03
上传时间:	2017-02-13T08:08:51Z (UTC)
出版者:	Elsevier B.V.
ISSN:	01674889
摘要:	Neural crest cells are multipotent progenitors that migrate extensively and differentiate into numerous derivatives. The developmental plasticity and migratory ability of neural crest cells render them an attractive model for studying numerous aspects of cell progression. We observed that zebrafish rgs2 was expressed in neural crest cells. Disrupting Rgs2 expression by using a dominant negative rgs2 construct or rgs2 morpholinos reduced GTPase-activating protein activity, induced the formation of neural crest progenitors, increased the proliferation of nonectomesenchymal neural crest cells, and inhibited the formation of ectomesenchymal neural crest derivatives. The transcription of pparda (which encodes Pparδ, a Wnt-activated transcription factor) was upregulated in Rgs2-deficient embryos, and Pparδ inhibition using a selective antagonist in the Rgs2-deficient embryos repaired neural crest defects. Our results clarify the mechanism through which the Rgs2–Pparδ cascade regulates neural crest development; specifically, Pparδ directly binds to the promoter and upregulates the transcription of the neural crest specifier sox10. This study reveals a unique regulatory mechanism, the Rgs2–Pparδ–Sox10 signaling cascade, and defines a key molecular regulator, Rgs2, in neural crest development.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/16943 http://dx.doi.org/10.1016/j.bbamcr.2016.12.013
關聯:	Biochimica et Biophysica Acta - Molecular Cell Research,Volume 1864, Issue 3, 1 March 2017, Pages 463-474
显示于类别:	[醫學應用化學系暨碩士班] 期刊論文

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