肺炎黴漿菌感染對不同年齡兒童氣喘發展之影響

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Title:	肺炎黴漿菌感染對不同年齡兒童氣喘發展之影響 The effect of Mycoplasma pneumoniae on the subsequent development of asthma in children with different age
Authors:	潘蕙嫻 Pan, Hui-Hsien
Contributors:	中山醫學大學:醫學研究所;呂克桓;柯俊良
Keywords:	氣喘;肺炎黴漿菌;兒童 asthma;mycoplasma pneumonia;children
Date:	2016
Issue Date:	2017-01-18T04:43:43Z (UTC)
Abstract:	研究背景：肺炎黴漿菌曾經被研究與氣喘的發生和持續相關。然而我們並不清楚對於台灣的兒童，感染黴漿菌肺炎是否影響日後氣喘的發生。研究方法：本研究從全民健康保險研究資料庫找出2003年到 2011年間新診斷為肺炎黴漿菌感染的兒童。在診斷肺炎黴漿菌感染之前即被診斷為氣喘的病人即被排除。肺炎黴漿菌感染的病童依年紀被分成三個族群(0-2歲，3-5歲及6-18歲)，我們依據出生年、性別及診斷肺炎黴漿菌感染的日期，從普通人口找出13284位沒有被診斷為肺炎黴漿菌感染的兒童來當對照組。有肺炎黴漿菌感染的兒童被追蹤至2011年底。我們用Cox競爭風險模式來計算感染肺炎黴漿菌在三個不同年齡層評估氣喘風險的風險比值。研究結果：排除共病的影響。在每個年齡層，感染肺炎黴漿菌的病人跟那些非肺炎黴漿菌感染的病人，有較高的氣喘發生率。和沒有感染肺炎黴漿菌的族群相較，有感染肺炎黴漿菌這個族群發生氣喘的風險比值在0-2歲、3-5歲及6-18歲分別是1.44﹝95%信賴區間為1.09-1.90﹞，2.19﹝95%信賴區間為1.82-2.63﹞及2.75﹝95%信賴區間為1.88-4.03﹞ 結論與建議：感染肺炎黴漿菌跟增加兒童氣喘的發生率相關，特別是6-18歲這個族群。 Background: Mycoplasma pneumoniae (MP) has been reported to be associated with initiation and persistence of asthma. It is unclear whether MP infection is associated with risk of developing asthma in Taiwanese children. Objective: We investigated the association between MP infection and risk of asthma in children. Methods: Pediatric patients newly diagnosed with MP between 2003 and 2011 were identified using National Health Insurance Research Database. Children with asthma before MP infection were excluded. Patients with MP infection (n= 3,321) were further analyzed by age (0-2, 3-5, and 6-18 years). We then frequency matched 13,284 patients without MP from the general population according to birth year, sex, and date of MP diagnosed. Subjects with MP were followed up until the end of 2011. Cox competing risk hazard model was used to calculate the hazard ratio (HR) of MP to estimate asthma risk in 3 age groups. Results: Regardless of comorbidities, patients with MP infection had a higher risk of incident asthma than those without it in each age group. Compared with non-MP cohorts, the HRs of asthma were 1.44 (95%CI, 1.09-1.90), 2.19 (95%CI, 1.82-2.63), and 2.75 (95%CI, 1.88-4.03) for children with MP infection at the age of 0-2, 3-5, and 6-18 years, respectively. Conclusions: MP was associated with increased risk of asthma in children, especially in children aged 6-18 years.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/16285
Appears in Collections:	[醫學研究所] 博碩士論文

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