Cytokine promoter polymorphisms in Taiwanese patients with Graves' disease

doi:10.1016/j.clinbiochem.2006.11.009

中山醫學大學機構典藏 CSMUIR > 醫學科技學院 > 醫學檢驗暨生物技術學系暨碩士班 > 期刊論文 > Item 310902500/15954

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题名:	Cytokine promoter polymorphisms in Taiwanese patients with Graves' disease
作者:	MY, Shiau CN, Huang TP, Yang YC, Hwang KJ, Tsai CJ, Chi YH, Chang
贡献者:	中山醫學大學
关键词:	TNF-α;IL-10;Promoter polymorphisms;Graves' disease
日期:	2007
上传时间:	2016-09-06T08:14:21Z (UTC)
ISSN:	0009-9120
摘要:	OBJECTIVES: This study aimed to examine the association between promoter polymorphisms of Th1 and Th2 cytokine genes [interleukin-4 (IL-4 T-34C, A-81G, C-285T and T-589C), IL-6 (G-174C), IL-10 (A-592C and T-819C) and tumour necrosis factor-alpha (TNF-alpha G-238A and G-308A)] and Graves' disease (GD) in Taiwanese population. DESIGN AND METHODS: Genomic DNA was extracted from peripheral blood cells of 137 GD patients and 189 control subjects. Cytokine gene polymorphisms were analyzed by polymerase chain reaction and restriction fragment length polymorphism. RESULTS: Genotype frequencies of TNF-alpha G-238A or G-308A between control and GD subjects were significantly different. Frequencies of the high TNF-alpha secreting alleles (-238A and -308A) and IL-10 -819*C allele were significantly increased in GD patients. No significant differences regarding IL-4 or IL-6 gene polymorphisms between GD patients and control subjects were found. CONCLUSIONS: Our data demonstrated that TNF-alpha G-238A and G-308A genotypes were strongly associated with GD incidence.
URI:	http://dx.doi.org/10.1016/j.clinbiochem.2006.11.009 https://ir.csmu.edu.tw:8080/ir/handle/310902500/15954
關聯:	Clinical Biochemistry Volume 40, Issues 3–4, February 2007, Pages 213–217
显示于类别:	[醫學檢驗暨生物技術學系暨碩士班] 期刊論文

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