Photocrosslinkable gellan gum film as an anti-adhesion barrier

中山醫學大學機構典藏 CSMUIR > 醫學科技學院 > 醫學檢驗暨生物技術學系暨碩士班 > 期刊論文 > Item 310902500/15924

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题名:	Photocrosslinkable gellan gum film as an anti-adhesion barrier
作者:	MW, Lee HF, Tsai SM, Wen CH, Huang
贡献者:	中山醫學大學
关键词:	Gellan gum;Cinnamate;Anti-adhesion
日期:	2012
上传时间:	2016-09-05T09:11:19Z (UTC)
ISSN:	0144-8617
摘要:	The purpose of this study was to develop a gellan gum-based film which could be photocrosslinked for medical applications. Gellan gum was grafted with cinnamate to yield the photo crosslinkable polymer (gellan gum-cin). This material had 14.7% of its D-galacturonic residues reacted with cinnamate groups and displayed maximum absorption at 254 nm. Investigation of the photochemical properties showed that the crosslinking efficiency was 82% after 16 min of UV irradiation. The anti-adhesion films prepared from gellan gum-cin polymers exhibited high gel contents (88 ± 2%) and suitable mechanical properties. When implanted into rats, the gellan gum-cin film exhibited the most promising anti-adhesion potential in 2 out of 10 rats without forming any tissue adhesion. Furthermore, the gellan gum-cin film could effectively inhibit inflammation in rats based on the results of fluid leukocyte analyses. The gellan gum-cin film thus has potential in clinical applications.
URI:	http://dx.doi.org/10.1016/j.carbpol.2012.06.064 https://ir.csmu.edu.tw:8080/ir/handle/310902500/15924
關聯:	Carbohydr Polym. 2012 Oct 1;90(2):1132-8
显示于类别:	[醫學檢驗暨生物技術學系暨碩士班] 期刊論文

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