The Methanol Extract of Angelica sinensis Induces Cell Apoptosis and Suppresses Tumor Growth in Human Malignant Brain Tumors

doi:10.1155/2013/394636

中山醫學大學機構典藏 CSMUIR > 醫學科技學院 > 醫學檢驗暨生物技術學系暨碩士班 > 期刊論文 > Item 310902500/15898

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/15898

Title:	The Methanol Extract of Angelica sinensis Induces Cell Apoptosis and Suppresses Tumor Growth in Human Malignant Brain Tumors
Authors:	Lin, Yu-Ling Lai, Wen-Lin Harn, Horng-jyh Hung, Pei-Hsiu Hsieh, Ming-Chang Chang, Kai-Fu Huang, Xiao-Fan Liao, Kuang-Wen Lee, Ming-Shih Tsai, Nu-Man
Contributors:	中山醫學大學
Date:	2013
Issue Date:	2016-09-05T07:29:08Z (UTC)
ISSN:	1741-427X
Abstract:	Glioblastoma multiforme (GBM) is a highly vascularized and invasive neoplasm. The methanol extract of Angelica sinensis (AS-M) is commonly used in traditional Chinese medicine to treat several diseases, such as gastric mucosal damage, hepatic injury, menopausal symptoms, and chronic glomerulonephritis. AS-M also displays potency in suppressing the growth of malignant brain tumor cells. The growth suppression of malignant brain tumor cells by AS-M results from cell cycle arrest and apoptosis. AS-M upregulates expression of cyclin kinase inhibitors, including p16, to decrease the phosphorylation of Rb proteins, resulting in arrest at the G0-G1 phase. The expression of the p53 protein is increased by AS-M and correlates with activation of apoptosis-associated proteins. Therefore, the apoptosis of cancer cells induced by AS-M may be triggered through the p53 pathway. In in vivo studies, AS-M not only suppresses the growth of human malignant brain tumors but also significantly prolongs patient survival. In addition, AS-M has potent anticancer effects involving cell cycle arrest, apoptosis, and antiangiogenesis. The in vitro and in vivo anticancer effects of AS-M indicate that this extract warrants further investigation and potential development as a new antibrain tumor agent, providing new hope for the chemotherapy of malignant brain cancer.
URI:	http://dx.doi.org/10.1155/2013/394636 https://ir.csmu.edu.tw:8080/ir/handle/310902500/15898
Relation:	Evidence-Based Complementary and Alternative Medicine Volume 2013 (2013), Article ID 394636, 9 pages
Appears in Collections:	[醫學檢驗暨生物技術學系暨碩士班] 期刊論文

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