Ameliorative effect of Pracparatum mungo extract on high cholesterol diets in hamsters.

doi:10.1039/c3fo60445d

中山醫學大學機構典藏 CSMUIR > 健康管理學院 > 健康餐飲暨產業管理學系暨碩士班 > 期刊論文 > Item 310902500/15841

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题名:	Ameliorative effect of Pracparatum mungo extract on high cholesterol diets in hamsters.
作者:	YL, Hsieh YH, Yeh YT, Lee CH, Hsieh
贡献者:	中山醫學大學
日期:	2013
上传时间:	2016-08-16T04:09:04Z (UTC)
ISSN:	2042-6496
摘要:	This study was designed to test the lipid-lowering and antioxidative activities of Pracparatum mungo extract (PME), in comparison to its components berberine and glycyrrhizin in cholesterol-fed hamsters. The PME and berberine significantly lowered the atherogenic index compared to glycyrrhizin and the control (P < 0.05). The hepatic HMG-CoA reductase activity was significantly lower in the PME and berberine groups than in the glycyrrhizin group (P < 0.05), while the hepatic ACAT activity was significantly decreased by all treatments with respect to the high cholesterol fed group (P < 0.05). The overall potential of the antioxidant system was significantly enhanced by the PME, berberine and glycyrrhizin supplements as the plasma and hepatic TBARS levels were lowered while the hepatic superoxide dismutase activity and glutathione levels, HMG-CoA reductase, LDL receptor, PPAR, SREBP-2 and CYP7A1 mRNA expressions were increased by the treatments of PME and berberine in comparison with the high cholesterol fed hamsters (P < 0.05). Collectively, these results suggest that the supplementation of PME, berberine and glycyrrhizin increased antioxidant activity in hamsters. Furthermore, we observed that PME and berberine groups promoted the excretion of neutral and acidic sterols (P < 0.05), that could contribute to explain the lower plasma and hepatic cholesterol levels found in the treated animals.
URI:	http://dx.doi.org/10.1039/c3fo60445d https://ir.csmu.edu.tw:8080/ir/handle/310902500/15841
關聯:	Food Funct. 2014 Jan;5(1):149-57
显示于类别:	[健康餐飲暨產業管理學系暨碩士班] 期刊論文

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