中山醫學大學機構典藏 CSMUIR:Item 310902500/15805
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    题名: Surface nanotopography of an anodized Ti–6Al–7Nb alloy enhances cell growth
    作者: Huang, Her-Hsiung
    Wu, Chia-Ping
    Sun, Ying-Sui
    Yang, Wei-En
    Lee, Tzu-Hsin
    贡献者: 中山醫大口腔科學研究所
    关键词: Ti–6Al–7Nb alloy;Electrochemical anodization;Surface nanotopography;Cell growth
    日期: 2014
    上传时间: 2016-08-15T06:08:24Z (UTC)
    ISSN: 0925-8388
    摘要: The α/β-type Ti–6Al–7Nb alloy is a potential replacement for α/β-type Ti–6Al–4V alloy, which is widely used in biomedical implant applications. The biological response to implant material is dependent on the surface characteristics of the material. In the present study, a simple and fast process was developed to perform an electrochemical anodization treatment on Ti–6Al–7Nb alloy. The proposed process yielded a thin surface nanotopography, which enhanced cell growth on the Ti–6Al–7Nb alloy. The surface characteristics, including the morphology, wettability, and protein adsorption, were investigated, and the cytotoxicity was evaluated according to International Organization for Standardization 10993-5 specifications. Cell adhesion of human bone marrow mesenchymal stem cells on the test specimens was observed via fluorescence microscopy and scanning electron microscopy. The anodization process produced a surface nanotopography (pore size <100 nm) on anodized Ti–6Al–7Nb alloy, which enhanced the wettability, protein adsorption, cell adhesion, cell migration, and cell mineralization. The results showed that the surface nanotopography produced using the proposed electrochemical anodization process enhanced cell growth on anodized Ti–6Al–7Nb alloy for implant applications.
    URI: http://dx.doi.org/10.1016/j.jallcom.2013.12.235
    https://ir.csmu.edu.tw:8080/ir/handle/310902500/15805
    關聯: Journal of Alloys and CompoundsVolume 615, Supplement 1, 5 December 2014, Pages S648–S654
    显示于类别:[口腔醫學研究所] 期刊論文

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