Surface nanotopography of an anodized Ti–6Al–7Nb alloy enhances cell growth

doi:10.1016/j.jallcom.2013.12.235

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 口腔醫學研究所 > 期刊論文 > Item 310902500/15805

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/15805

Title:	Surface nanotopography of an anodized Ti–6Al–7Nb alloy enhances cell growth
Authors:	Huang, Her-Hsiung Wu, Chia-Ping Sun, Ying-Sui Yang, Wei-En Lee, Tzu-Hsin
Contributors:	中山醫大口腔科學研究所
Keywords:	Ti–6Al–7Nb alloy;Electrochemical anodization;Surface nanotopography;Cell growth
Date:	2014
Issue Date:	2016-08-15T06:08:24Z (UTC)
ISSN:	0925-8388
Abstract:	The α/β-type Ti–6Al–7Nb alloy is a potential replacement for α/β-type Ti–6Al–4V alloy, which is widely used in biomedical implant applications. The biological response to implant material is dependent on the surface characteristics of the material. In the present study, a simple and fast process was developed to perform an electrochemical anodization treatment on Ti–6Al–7Nb alloy. The proposed process yielded a thin surface nanotopography, which enhanced cell growth on the Ti–6Al–7Nb alloy. The surface characteristics, including the morphology, wettability, and protein adsorption, were investigated, and the cytotoxicity was evaluated according to International Organization for Standardization 10993-5 specifications. Cell adhesion of human bone marrow mesenchymal stem cells on the test specimens was observed via fluorescence microscopy and scanning electron microscopy. The anodization process produced a surface nanotopography (pore size <100 nm) on anodized Ti–6Al–7Nb alloy, which enhanced the wettability, protein adsorption, cell adhesion, cell migration, and cell mineralization. The results showed that the surface nanotopography produced using the proposed electrochemical anodization process enhanced cell growth on anodized Ti–6Al–7Nb alloy for implant applications.
URI:	http://dx.doi.org/10.1016/j.jallcom.2013.12.235 https://ir.csmu.edu.tw:8080/ir/handle/310902500/15805
Relation:	Journal of Alloys and CompoundsVolume 615, Supplement 1, 5 December 2014, Pages S648–S654
Appears in Collections:	[口腔醫學研究所] 期刊論文

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