Induction of vascular endothelial growth factor expression in human pulp fibroblasts stimulated with black-pigmented Bacteroides.

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/15780

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题名:	Induction of vascular endothelial growth factor expression in human pulp fibroblasts stimulated with black-pigmented Bacteroides.
作者:	LC, Yang CH, Tsai FM, Huang YF, Su CC, Lai CM, Liu YC, Chang
贡献者:	中山醫大口腔科學研究所
日期:	2004-08-17
上传时间:	2016-08-15T03:17:43Z (UTC)
ISSN:	0143-2885
摘要:	AIM: To investigate the effect of black-pigmented Bacteroides on the expression of vascular endothelial growth factor (VEGF) gene in human pulp fibroblasts. METHODOLOGY: The supernatants of Porphyromonas endodontalis, Porphyromonas gingivalis and Prevotella intermedia were used to evaluate VEGF gene expression in human pulp fibroblasts. The levels of mRNAs were measured by the quantitative reverse-transcriptase polymerase chain reaction analysis. RESULTS: Black-pigmented Bacteroides induced significantly high levels of VEGF mRNA gene expression in human pulp fibroblasts (P < 0.05). In addition, the expression of VEGF depended on the bacteria tested. CONCLUSIONS: Black-pigmented Bacteroides may be involved in developing pulpal disease through the stimulation of VEGF production that would lead to the expansion of the vascular network coincident to progression of the inflammation.
URI:	http://dx.doi.org/10.1111/j.1365-2591.2004.00847.x https://ir.csmu.edu.tw:8080/ir/handle/310902500/15780
關聯:	Int Endod J. 2004 Sep;37(9):588-92.
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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