Elevated erythrocyte carbonic anhydrase activity is a novel clinical marker in hyperventilation syndrome.

doi:10.1515/CCLM.2009.102

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/15778

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题名:	Elevated erythrocyte carbonic anhydrase activity is a novel clinical marker in hyperventilation syndrome.
作者:	YH1, Teng HT, Tsai YS, Hsieh YC, Chen CW, Lin MC, Lee LY, Lin SF, Yang
贡献者:	中山醫大口腔科學研究所
关键词:	erythrocyte carbonic anhydrase activity;hyperventilation syndrome
日期:	2009
上传时间:	2016-08-11T07:41:19Z (UTC)
ISSN:	1434-6621
摘要:	BACKGROUND: The aim of this study was to evaluate the erythrocyte carbonic anhydrase (CA) activity in patients with hyperventilation syndrome. METHODS: A total of 71 patients with hyperventilation syndrome and 60 controls were recruited in this study for measurement of the erythrocyte CA activity. CA activity was analyzed from erythrocyte using CA esterase activity analysis. RESULTS: The erythrocyte CA activity was significantly elevated in the patients with hyperventilation syndrome compared to controls (31.07+/-1.37 U/g Hb vs. 24.67+/-0.99 U/g Hb, p=0.003). The standardized beta value and significant R(2) value of total CA activity for prediction of hyperventilation was 0.155 (p=0.016) and 0.024, respectively. Moreover, a significant negative correlation was found between total CA activity and partial pressure of carbon dioxide (PaCO(2)) (r=-0.185, p=0.03, n=131). Furthermore, the adjusted odds ratios for patients with hyperventilation were 11.6 (95% CI: 4.8-27.9) and 51.0 (95% CI: 5.8-445.2) for individuals with either PaCO(2)<or=28.1 mm Hg or CA activity >or=29.71 U/g hemoglobin (Hb), and for individuals with both PaCO(2)<or=28.1 mm Hg and CA activity >or=29.71 U/g Hb, respectively, compared to individuals with both PaCO(2)>28.1 mm Hg and CA activity <29.71 U/g Hb. CONCLUSIONS: Erythrocyte CA activity was significantly elevated in patients with hyperventilation. Detection of erythrocyte CA activity may provide a potential explanatory parameter for the prediction of hyperventilation syndrome.
URI:	http://dx.doi.org/10.1515/CCLM.2009.102 https://ir.csmu.edu.tw:8080/ir/handle/310902500/15778
關聯:	Clin Chem Lab Med. 2009;47(4):441-5
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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