CCR2-64I gene polymorphism increase susceptibility to oral cancer

doi:10.1016/j.oraloncology.2011.04.008

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/15772

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题名:	CCR2-64I gene polymorphism increase susceptibility to oral cancer
作者:	MK, Chen KT, Yeh HL, Chiou CW, Lin TT, Chung SF, Yang
贡献者:	中山醫大口腔科學研究所
日期:	2011-05-12
上传时间:	2016-08-11T07:25:48Z (UTC)
ISSN:	1368-8375
摘要:	The purpose of this study was to investigate the impact of MCP-1 and its receptor CCR2 gene polymorphisms on the susceptibility and clinicopathological characteristics of oral cancer, as well as the synergistic effect between these gene polymorphisms and well-known risk factors including alcohol, tobacco, and areca consumptions. Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique for polymorphism analysis, 344 healthy controls and 216 oral cancer patients were recruited to reveal a significant association between V64I CCR2 gene polymorphism and oral cancer susceptibility. After adjusting for other confounders, individuals with GA (AOR=1.84; 95%CI=1.10-3.20) or at least one A allele (AOR=1.78; 95%CI=1.05-3.02) had a higher risk for oral cancer, compared to GG genotypes. Moreover, results also revealed that for subjects with GA or at least one A allele of V64I CCR2 gene polymorphism, those exposed to environmental risk factors possessed a significantly higher risk for oral cancer than those unexposed subjects. Therefore, genetic polymorphism of CCR2-64I may contribute to the susceptibility to oral cancer.
URI:	http://dx.doi.org/10.1016/j.oraloncology.2011.04.008 https://ir.csmu.edu.tw:8080/ir/handle/310902500/15772
關聯:	Oral Oncol. 2011 Jul;47(7):577-82
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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