Association between polymorphisms of DNA repair gene ERCC5 and oral squamous cell carcinoma.

doi:10.1016/j.oooo.2012.05.013

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/15762

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题名:	Association between polymorphisms of DNA repair gene ERCC5 and oral squamous cell carcinoma.
作者:	AI, Zavras AJ, Yoon MK, Chen CW, Lin SF, Yang
贡献者:	中山醫大口腔科學研究所
关键词:	DNA repair;gene polymorphism;hOGG1;type 2 diabetes mellitus;XRCC1
日期:	2012-09-12
上传时间:	2016-08-11T06:56:54Z (UTC)
ISSN:	http://dx.doi.org/
摘要:	OBJECTIVE: Short nucleotide polymorphism in ERCC5 (rs751402), a key molecule in DNA damage repair, was analyzed in 575 individuals who were either control subjects with no clinical evidence of malignant transformation of the oral mucosa or subjects with oral squamous cell carcinoma (OSCC). STUDY DESIGN: All participants provided a blood sample, demographic data, and information on habitual use of tobacco, alcohol, and areca nut. RESULTS: rs751402 homozygocity for C allele was found to confer a statistically significant protection against OSCC (adjusted odds ratio 0.56, 95% confidence interval 0.35-0.89; P = .01), whereas rs751402 T alleles were associated with increased risk. CONCLUSIONS: Our findings suggest that there is an association between rs751402 polymorphism and incidence of oral cancer. ERCC rs751402 CC genotype is significantly associated with decreased risk of OSCC, whereas the T allotype is correlated with higher risk of OSCC.
URI:	http://dx.doi.org/10.1016/j.oooo.2012.05.013 https://ir.csmu.edu.tw:8080/ir/handle/310902500/15762
關聯:	Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Nov;114(5):624-9.
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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