中山醫學大學機構典藏 CSMUIR:Item 310902500/15761
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    题名: Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer.
    作者: CW, Lin
    SW, Tseng
    SF, Yang
    CP, Ko
    CH, Lin
    LH, Wei
    MH, Chien
    YS, Hsieh
    贡献者: 中山醫大口腔科學研究所
    日期: 2012-04-26
    上传时间: 2016-08-11T06:51:45Z (UTC)
    ISSN: 1354-523X
    摘要: OBJECTIVES:

    Recent evidence demonstrated that lipocalin (LCN)2 is induced in many types of human cancer, while the detection of its complex with matrix metalloproteinase (MMP)-9 is correlated with the cancer disease status. We attempted to evaluate plasma expressions of LCN2, MMP-9, and their complex (LCN2/MMP-9) during the diagnostic work-up of patients with oral squamous cell carcinoma (OSCC) and investigated their correlations with disease progression.

    METHODS:

    In total, 195 patients with OSCC and 81 healthy controls were recruited. Expression levels of LCN2, MMP-9, and LCN2/MMP-9 were determined with immunoenzymatic assays.

    RESULTS:

    Patients with OSCC exhibited significantly higher levels of LCN2, MMP-9, and LCN2/MMP-9 compared with healthy controls (LCN2: P < 0.001; MMP-9: P < 0.001; LCN2/MMP-9: P < 0.01). Plasma levels of LCN2, MMP-9, and LCN2/MMP-9 in patients with OSCC were significantly correlated with each other and were associated with more-advanced clinical stages (P < 0.05) and/or a larger tumor size (P < 0.05), but were not associated with positive lymph-node metastasis or distal metastasis.

    CONCLUSION:

    Our results suggest that plasma levels of LCN2 and the LCN2/MMP-9 complex may be useful in non-invasively monitoring OSCC progression, while supporting their potential role as biomarkers of oral cancer disease status.
    URI: http://dx.doi.org/10.1111/j.1601-0825.2012.01938.x
    https://ir.csmu.edu.tw:8080/ir/handle/310902500/15761
    關聯: Oral Dis. 2012 Nov;18(8):734-40
    显示于类别:[牙醫學系暨碩士班] 期刊論文

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