Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer.

doi:10.1111/j.1601-0825.2012.01938.x

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/15761

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/15761

Title:	Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer.
Authors:	CW, Lin SW, Tseng SF, Yang CP, Ko CH, Lin LH, Wei MH, Chien YS, Hsieh
Contributors:	中山醫大口腔科學研究所
Date:	2012-04-26
Issue Date:	2016-08-11T06:51:45Z (UTC)
ISSN:	1354-523X
Abstract:	OBJECTIVES: Recent evidence demonstrated that lipocalin (LCN)2 is induced in many types of human cancer, while the detection of its complex with matrix metalloproteinase (MMP)-9 is correlated with the cancer disease status. We attempted to evaluate plasma expressions of LCN2, MMP-9, and their complex (LCN2/MMP-9) during the diagnostic work-up of patients with oral squamous cell carcinoma (OSCC) and investigated their correlations with disease progression. METHODS: In total, 195 patients with OSCC and 81 healthy controls were recruited. Expression levels of LCN2, MMP-9, and LCN2/MMP-9 were determined with immunoenzymatic assays. RESULTS: Patients with OSCC exhibited significantly higher levels of LCN2, MMP-9, and LCN2/MMP-9 compared with healthy controls (LCN2: P < 0.001; MMP-9: P < 0.001; LCN2/MMP-9: P < 0.01). Plasma levels of LCN2, MMP-9, and LCN2/MMP-9 in patients with OSCC were significantly correlated with each other and were associated with more-advanced clinical stages (P < 0.05) and/or a larger tumor size (P < 0.05), but were not associated with positive lymph-node metastasis or distal metastasis. CONCLUSION: Our results suggest that plasma levels of LCN2 and the LCN2/MMP-9 complex may be useful in non-invasively monitoring OSCC progression, while supporting their potential role as biomarkers of oral cancer disease status.
URI:	http://dx.doi.org/10.1111/j.1601-0825.2012.01938.x https://ir.csmu.edu.tw:8080/ir/handle/310902500/15761
Relation:	Oral Dis. 2012 Nov;18(8):734-40
Appears in Collections:	[牙醫學系暨碩士班] 期刊論文

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