The CCN family proteins: modulators of bone development and novel targets in bone-associated tumors.

doi:10.1155/2014/437096

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/15751

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/15751

Title:	The CCN family proteins: modulators of bone development and novel targets in bone-associated tumors.
Authors:	PC, Chen HC, Cheng SF, Yang CW, Lin CH, Tang
Contributors:	中山醫大口腔科學研究所
Date:	2011-01-14
Issue Date:	2016-08-11T06:20:21Z (UTC)
ISSN:	2314-6133
Abstract:	The CCN family of proteins is composed of six extracellular matrix-associated proteins that play crucial roles in skeletal development, wound healing, fibrosis, and cancer. Members of the CCN family share four conserved cysteine-rich modular domains that trigger signal transduction in cell adhesion, migration, proliferation, differentiation, and survival through direct binding to specific integrin receptors and heparan sulfate proteoglycans. In the present review, we discuss the roles of the CCN family proteins in regulating resident cells of the bone microenvironment. In vertebrate development, the CCN family plays a critical role in osteo/chondrogenesis and vasculo/angiogenesis. These effects are regulated through signaling via integrins, bone morphogenetic protein, vascular endothelial growth factor, Wnt, and Notch via direct binding to CCN family proteins. Due to the important roles of CCN family proteins in skeletal development, abnormal expression of CCN proteins is related to the tumorigenesis of primary bone tumors such as osteosarcoma, Ewing sarcoma, and chondrosarcoma. Additionally, emerging studies have suggested that CCN proteins may affect progression of secondary metastatic bone tumors by moderating the bone microenvironment. CCN proteins could therefore serve as potential therapeutic targets for drug development against primary and metastatic bone tumors.
URI:	http://dx.doi.org/10.1155/2014/437096 https://ir.csmu.edu.tw:8080/ir/handle/310902500/15751
Relation:	Biomed Res Int. 2014;2014:437096
Appears in Collections:	[牙醫學系暨碩士班] 期刊論文

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