Carbonic anhydrase IX overexpression regulates the migration and progression in oral squamous cell carcinoma.

doi:10.1007/s13277-015-3692-8

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/15735

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题名:	Carbonic anhydrase IX overexpression regulates the migration and progression in oral squamous cell carcinoma.
作者:	JS, Yang CW, Lin CY, Chuang SC, Su SH, Lin SF, Yang
贡献者:	中山醫大口腔科學研究所
关键词:	CAIX;Migration;OSCC;Prognosis;Tissue microarray
日期:	2015-07-01
上传时间:	2016-08-11T04:01:52Z (UTC)
ISSN:	1010-4283
摘要:	Carbonic anhydrase IX (CAIX) is reportedly overexpressed in several types of carcinomas and is generally considered a marker of malignancy. The current study investigated the association between membrane expression of CAIX and the clinicopathological characteristics in oral squamous cell carcinoma (OSCC) patients. The study used immunohistochemistry to examine CAIX expression in 271 OSCC specimens by tissue microarray (TMA) and assessed the effect of CAIX overexpression and knockdown on migration of oral cancer cells in vitro. We found that CAIX expression was associated with more advanced clinical stages (p = 0.030) and positive lymph node metastasis (p = 0.026). Importantly, CAIX expression was correlated with a poorer patient prognosis in a univariate survival analysis (p = 0.025). Moreover, CAIX suppression by small interfering RNA (siRNA) significantly reduced cellular migration in OECM-1 oral cancer cell. In conclusion, our study showed that the expression of CAIX in OSCC samples can predict the progression of OSCC and survival of OSCC patients in Taiwan.
URI:	http://dx.doi.org/10.1007/s13277-015-3692-8 https://ir.csmu.edu.tw:8080/ir/handle/310902500/15735
關聯:	Tumour Biol. 2015 Dec;36(12):9517-24
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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