Hispolon suppresses migration and invasion of human nasopharyngeal carcinoma cells by inhibiting the urokinase-plasminogen activator through modulation of the Akt signaling pathway.

doi:10.1002/tox.22266

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/15730

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/15730

Title:	Hispolon suppresses migration and invasion of human nasopharyngeal carcinoma cells by inhibiting the urokinase-plasminogen activator through modulation of the Akt signaling pathway.
Authors:	HY, Ho YC, Ho MJ, Hsieh SF, Yang CY, Chuang CW, Lin CH, Hsin
Contributors:	中山醫大口腔科學研究所
Keywords:	hispolon;migration;nasopharyngeal carcinoma;uPA
Date:	2016-03-31
Issue Date:	2016-08-11T03:49:37Z (UTC)
ISSN:	1520-4081
Abstract:	Hispolon has been reported to possess antioxidant, antiinflammatory, and antitumor activities. However, the effect of hispolon on the metastasis of nasopharyngeal carcinoma (NPC) remains unclear. In this study, we investigated how the antimetastatic activity and relevant signaling pathways of hispolon affected three NPC cell lines. The results revealed that hispolon significantly reduced the migration and invasion of three NPC cells in a dose-dependent manner from 0 to 50 µM. Hispolon also significantly inhibited the activity and expression of urokinase-plasminogen activator (uPA) as well as the phosphorylation of Akt. Moreover, blocking the Akt pathway also enhanced the antimetastatic ability of hispolon in the NPC cells. In conclusion, hispolon inhibited uPA expression and NPC cell metastasis by downregulating Akt signal pathways; therefore, hispolon exerts beneficial effects in chemoprevention. © 2016 Wiley Periodicals, Inc. Environ Toxicol, 2016.
URI:	http://dx.doi.org/10.1002/tox.22266 https://ir.csmu.edu.tw:8080/ir/handle/310902500/15730
Relation:	Environ Toxicol. 2016 Mar 31
Appears in Collections:	[牙醫學系暨碩士班] 期刊論文

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