In vitro antimicrobial and anticancer potential of hinokitiol against oral pathogens and oral cancer cell lines.

doi:10.1016/j.micres.2012.12.007

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/15707

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/15707

题名:	In vitro antimicrobial and anticancer potential of hinokitiol against oral pathogens and oral cancer cell lines.
作者:	YH, Shih;KW, Chang;SM, Hsia;CC, Yu;LJ, Fuh;TY, Chi;TM, Shieh
贡献者:	中山醫學大學
关键词:	Autolysin;Hinokitiol;Minimal inhibitory concentrations;Minimal microbicidal concentration;Oral squamous cell carcinoma;Paradoxical inhibition phenomenon (PIP)
日期:	2013-06-12
上传时间:	2016-08-09T09:06:03Z (UTC)
ISSN:	0944-5013
摘要:	Hinokitiol is a natural component isolated from Chamacyparis taiwanensis. It has anti-microbial activity, and has been used in oral care products. The minimal inhibitory concentration (MIC) and minimal microbicidal concentration (MMC) of hinokitiol against MRSA, Aggregatibacter actinomycetemcomitans, Streptococcus mutans, and Candida albicans were determined by the agar and broth dilution method (MIC: 40-110μM; MMC: 50-130μM); the paradoxical inhibition phenomenon (PIP) was observed in A. actinomycetemcomitans and S. mutans. The PIP can be described as microbial growth occurring in the presence of both high and low concentrations of a compound, between which microbial growth is inhibited. The PIP was confirmed using a kinetic microplate and inhibition zone methods. The PIP was also observed in MRSA. The low autolysin activity somehow correlated to the PIP positive. The cell diameter was increased in all the pathogens, and the transition was inhibited in C. albicans following hinokitiol treatment. Hinokitiol is also a potential anticancer drug. The 200μM of hinokitiol has significant antimicrobial and cytotoxic activities against oral pathogens and oral squamous cell carcinoma cell lines, respectively, and lower cytotoxic effects for normal human oral keratinocytes, indicating that hinokitiol displays a high potential for safe and effective applications in oral health care.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/15707 http://dx.doi.org/10.1016/j.micres.2012.12.007
關聯:	Microbiol Res. 2013 Jun 12;168(5):254-62.
显示于类别:	[牙醫學系暨碩士班] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	399	检视/开启

检视Licence

在CSMUIR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....