中山醫學大學機構典藏 CSMUIR:Item 310902500/15703
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    題名: Inhibitory effects of wogonin on invasion by human oral cancer cells by decreasing the activity of matrix metalloproteinases and urokinase-plasminogen activator
    作者: Ho, Yung-Chuan;Lee, Shiuan-Shinn;Yang, Shun-Fa;Yu, Cheng-Chia;Changd, Yu-Chao
    貢獻者: 中山醫大口腔科學研究所
    關鍵詞: invasion;matrix metalloproteinases;urokinase plasminogen activator;wogonin
    日期: 2014-06
    上傳時間: 2016-08-09T08:47:27Z (UTC)
    ISSN: 1991-7902
    摘要: Background/purpose

    Wogonin (5,7-dihydroxy-8-methoxyflavone) is a bioactive compound from Scutellariae radix that has been shown to have anticancer effects. However, the effects of wogonin on oral cancer cells still remain speculative.

    Materials and methods

    Cytotoxicity and invasion assays were used to investigate the effects of the human oral cancer cell line OC2 cells exposed to wogonin. To examine the precise involvement of wogonin in cancer metastasis, gelatin and casein zymography were performed to evaluate the impacts of wogonin on matrix metalloproteinase (MMP)-2, MMP-9, and urokinase plasminogen activator (u-PA) secretion in OC2 cells.

    Results

    Wogonin exhibited a dose-dependent inhibitory effect on the invasion of OC2 cells in the absence of cytotoxicity (P < 0.05). Wogonin was also found to decrease the expressions of MMP-2, MMP-9, and u-PA in a concentration-dependent manner (P < 0.05).

    Conclusion

    Taken together, these results suggest that wogonin could inhibit invasion by human oral cancer cells and the inhibitory effects may partially be due to decreased production of MMP-2, MMP-9, and u-PA.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/15703
    http://dx.doi.org/10.1016/j.jds.2013.02.024
    關聯: Journal of Dental Sciences Volume 9, Issue 2, June 2014, Pages 172–177
    顯示於類別:[口腔醫學研究所] 期刊論文

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