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    Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/15700


    Title: Targeting CD133 in the enhancement of chemosensitivity in oral squamous cell carcinoma-derived side population cancer stem cells.
    Authors: CC, Yu;FW, Hu;CH, Yu;MY, Chou
    Contributors: 中山醫大口腔科學研究所
    Keywords: CD133;cancer stem cells;chemosensitivity;oral squamous cell carcinomas;side population
    Date: 2015-06-04
    Issue Date: 2016-08-09T08:35:11Z (UTC)
    ISSN: 1043-3074
    Abstract: BACKGROUND:
    Oral squamous cell carcinoma (OSCC) is one of the most common cancers in the world. Previously, we enriched a subpopulation of OSCC-derived cancer stem cells (OSCC-CSCs), and identified CD133 as an OSCC-CSC marker.
    METHOD:
    We determined the function of CD133 on chemosensitivity of oral cancer CSCs by silencing CD133.
    RESULTS:
    Initially, we observed that the expression profile of CD133 in OSCC-side population (OSCC-SPs) cells, which exerted properties of CSCs, was significantly upregulated than that of major population (MPs) cells of OSCCs. The cell viability experiments showed that SPs were more chemoresistant compared with major populations. Importantly, targeting CD133 ameliorated the drug resistance of OSCC-SPs to cisplatin treatment. Targeting CD133 and cisplatin co-treatment led to the maximal inhibition on tumor initiating properties in OSCC-SPs.
    CONCLUSION:
    Side population cells with CSCs properties existed in OSCCs, and silencing CD133 exhibited a prominent therapeutic effect in enhancing the sensitivity of chemotherapy in OSCC through elimination of CSCs. © 2015 Wiley Periodicals, Inc. Head Neck 38: E231-E238, 2016.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/15700
    http://dx.doi.org/10.1002/hed.23975
    Relation: Head Neck. 2016 Apr;38 Suppl 1:E231-8.
    Appears in Collections:[牙醫學系暨碩士班] 期刊論文

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