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    Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/15695


    Title: Plasminogen activator inhibitor-1 as regulator of tumor-initiating cell properties in head and neck cancers.
    Authors: YC, Lee;CC, Yu;Lan, C;CH, Lee;HT, Lee;YL, Kuo;PH, Wang;WW, Chang
    Contributors: 中山醫大口腔科學研究所
    Keywords: Sox2;head and neck cancer;plasminogen activator inhibitor-1 (PAI-1);tiplaxtinin (PAI-039);tumor-initiating cells
    Date: 2016-04
    Issue Date: 2016-08-09T08:15:32Z (UTC)
    ISSN: 1043-3074
    Abstract: BACKGROUND:
    The existence of tumor-initiating cells (TICs) has been described in head and neck cancers. Plasminogen activator inhibitor-1 (PAI-1) has been demonstrated to act as a prognostic factor in head and neck cancers.
    METHODS:
    Tiplaxtinin (PAI-039), a specific inhibitor of PAI-1, and PAI-1-specific siRNA were used to examine the role of PAI-1 in the self-renewal property of head and neck cancer-TICs by tumorsphere formation. Western blot, real-time polymerase chain reaction, and luciferase-based reporter assay were used to study the effect of PAI-039 in the sex-determining region Y-box 2 (Sox2) expression.
    RESULTS:
    PAI-039 suppressed the self-renewal capability of head and neck cancer-TICs derived from head and neck cancer cell lines through the inhibition of Sox2 expression. PAI-039 decreased the activity of the core promoter and the enhancer of the Sox2 gene in head and neck cancer-TICs. Knockdown of PAI-1 expression also inhibited self-renewal and radioresistance properties of head and neck cancer-TICs.
    CONCLUSION:
    The inhibition of PAI-1 by PAI-039 or siRNA could suppress head and neck cancer-TICs within head and neck cancer cell lines through the downregulation of Sox2. © 2015 Wiley Periodicals, Inc. Head Neck 38: E895-E904, 2016.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/15695
    Relation: Head Neck. 2016 Apr;38 Suppl 1:E895-904.
    Appears in Collections:[牙醫學系暨碩士班] 期刊論文

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