Identification of phostensin, a PP1 F-actin cytoskeleton targeting subunit.

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 口腔醫學研究所 > 期刊論文 > Item 310902500/15670

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题名:	Identification of phostensin, a PP1 F-actin cytoskeleton targeting subunit.
作者:	SC, Kao;CY, Chen;SL, Wang;JJ, Yang;WC, Hung;YC, Chen;NS, Lai;HT, Liu;HL, Huang;HC, Chen;TH, Lin;HB, Huang
贡献者:	中山醫大口腔科學研究所
关键词:	Phostensin;KIAA1949;Protein phosphatase 1;Actin cytoskeleton
日期:	2007-05-11
上传时间:	2016-08-09T04:23:31Z (UTC)
摘要:	We have identified a novel protein, protein phosphatase 1 F-actin cytoskeleton targeting subunit (phostensin). This protein is encoded by KIAA1949 and was found to associate with protein phosphatase 1 (PP1) in the yeast two-hybrid assay, co-immunoprecipitation, and GST pull-down assay. Northern blot analysis revealed that phostensin mRNA was predominantly distributed in leukocytes and spleen, and phostensin protein was present in crude extracts of human peripheral leukocytes. Immunofluorescence microscopic analysis revealed that the phostensin/PP1 complex was conspicuously localized with the actin cytoskeleton at the cell periphery in Madin–Darby canine kidney (MDCK) epithelial cells. Taken together, our data shows that phostensin targets PP1 to F-actin cytoskeleton. The phostensin/PP1 complex may play a vital role in modulation of actin rearrangements.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/15670
關聯:	Biochem Biophys Res Commun. 2007 May 11;356(3):594-8.
显示于类别:	[口腔醫學研究所] 期刊論文

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