中山醫學大學機構典藏 CSMUIR:Item 310902500/15664
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    题名: Interaction abolishment between mutant caveolin-1Δ62–100 and ABCA1 reduces HDL-mediated cellular cholesterol efflux
    作者: Kuo, Chan-Yen;Lin, Yu-Chun;Yang, Jaw-Ji;Vivian, C.Yang
    贡献者: 中山醫大口腔科學研究所
    关键词: Caveolin-1Δ62–100;ABCA1;Oligomerization;Cholesterol efflux
    日期: 2011-10-11
    上传时间: 2016-08-05T07:45:38Z (UTC)
    出版者: Elsevier
    ISSN: 0006-291X
    摘要: Our previous study shows that caveolin-1 colocalizes and interacts with ATP-binding cassette transporter A1 (ABCA1), which is intimately involved in cellular cholesterol efflux. In this study, we further clarified the region of caveolin-1 that interacts with ABCA1. We also examined the interaction between mutant caveolin-1 and ABCA1 in HDL-mediated cholesterol efflux. We constructed a panel of mutant caveolin-1 proteins and co-transfected them into rat aortic endothelial and human embryonic kidney 293 (HEK293) cells. The co-immunoprecipitation shows that mutant oligomerization domain of caveolin-1, caveolin-1Δ62–100, is required for the interaction of caveolin-1 with ABCA1. Caveolin-1Δ62–100 did not colocalize with ABCA1 in the cholesterol-loaded cells after HDL incubation as observed by immunofluorescence confocal microscopy. Concomitantly, caveolin-1Δ62–100 suppressed HDL-mediated cholesterol efflux. The results suggest that the region of caveolin-1 between amino acids 62 and 100 is an oligomerization domain as well as an attachment site for ABCA1 interaction that regulates HDL-mediated cholesterol efflux.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/15664
    http://dx.doi.org/10.1016/j.bbrc.2011.09.070
    關聯: Biochemical and Biophysical Research Communications Volume 414, Issue 2, 22 October 2011, Pages 337–343
    显示于类别:[口腔醫學研究所] 期刊論文

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