中山醫學大學機構典藏 CSMUIR:Item 310902500/15663
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    题名: Phosphorylation of serine-504 of tNOX (ENOX2) modulates cell proliferation and migration in cancer cells
    作者: Zeng, Zih-Ming;Chuang, Show-Mei;Chang, Ting-Chia;Hong, Chen-Wei;Chou, Jou-Chun;Yang, Jaw-Ji;Chueh, Pin Ju
    贡献者: 中山醫大口腔科學研究所
    关键词: Phosphorylation;Protein kinase Cδ (PKCδ);Tumor-associated NADH oxidase (tNOX, ENOX2);Proliferation;Migration
    日期: 2012-08-15
    上传时间: 2016-08-05T07:42:21Z (UTC)
    出版者: Elsevier
    ISSN: 0014-4827
    摘要: Tumor-associated NADH oxidase (tNOX; ENOX2) is a growth-related protein expressed in transformed cells. Consistent with this function, tNOX knockdown by RNA interference leads to a significant reduction in cell proliferation and migration in HeLa cells, whereas tNOX overexpression confers an aggressive phenotype. Here, for the first time, we report that tNOX is phosphorylated by protein kinase Cδ (PKCδ) both in vitro and in vivo. Replacement of serine-504 with alanine significantly reduces phosphorylation by PKCδ. Co-immunoprecipitation experiments reveal an interaction between tNOX and PKCδ. Moreover, whereas overexpression of wild-type tNOX in NIH3T3 cells increases cell proliferation and migration, overexpression of the S504A tNOX mutant leads to diminished cell proliferation and migration, reflecting reduced stability of the unphosphorylatable tNOX mutant protein. Collectively, these results suggest that phosphorylation of serine-504 by PKCδ modulates the biological function of tNOX.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/15663
    http://dx.doi.org/10.1016/j.yexcr.2012.04.021
    關聯: Experimental Cell Research Volume 318, Issue 14, 15 August 2012, Pages 1759–1766
    显示于类别:[口腔醫學研究所] 期刊論文

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