Urinary levels of 1-hydroxypyrene in children residing near a coal-fired power plant

doi:10.1016/j.envres.2011.07.004

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Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/15651

Title:	Urinary levels of 1-hydroxypyrene in children residing near a coal-fired power plant
Authors:	Hu, Suh-Woan;Chan, Yun-Jung;Hsu, Hui-Tsung;Wu, Kuen-Yuh;ChangChien, Guo-Ping;Shiec, Ruei-Hao;Chan, Chang-Chuan
Contributors:	中山醫學大學口腔科學研究所
Keywords:	1-hydroxypyrene;Children;Power plant;Polycyclic aromatic hydrocarbons;Biomarker
Date:	2011
Issue Date:	2016-08-05T06:04:40Z (UTC)
ISSN:	0013-9351
Abstract:	Background The effects of emissions from coal-fired power plants on children's exposure to polycyclic aromatic hydrocarbons (PAHs) are not well understood. Objectives This study aimed to evaluate the sources and the urinary levels of 1-hydroxypyrene, a biomarker of exposure to PAHs, among children living in proximity to a coal-fired power plant. Methods Study areas consisted of two high exposure and two low exposure communities, at different distances and directions from a large coal-fired power plant in central Taiwan. Study subjects included 369 children aged 1–13 years and randomly selected from each community. Each child's urinary 1-hydroxypyrene concentration was measured by a high-performance liquid chromatography-fluorescence detector method. Samples of ambient air were analyzed for PAHs using a gas chromatography–mass spectrometry method. Information on important factors was collected by an interview using a structured questionnaire. Multiple regression analysis was used to assess factors significantly associated with urinary 1-hydroxypyrene levels. Results Levels of PAHs in ambient air in the high exposure communities were higher than those in the low exposure communities. Children living in high exposure communities had higher mean urinary 1-hydroxypyrene concentrations than those in low exposure communities (0.186 and 0.194 vs. 0.113 and 0.122 μmol/mol-creatinine, respectively). The difference in urinary 1-hydroxypyrene levels between the high exposure communities and one low exposure community remained significant after adjusting for age, gender, environmental tobacco smoke, dietary exposure, and traffic. Conclusions Children living in communities downwind of and in proximity to the coal-fired power plant had significantly increased urinary 1-hydroxypyrene levels. Highlights ► Children living near the power plant had increased urinary 1-hydroxypyrene levels. ► Communities near the plant had higher gas-phase polycyclic aromatic hydrocarbons. ► The power plant may affect children's exposure to polycyclic aromatic hydrocarbons. Abbreviations IQR, inter-quartile range; PAHs, polycyclic aromatic hydrocarbons
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/15651 http://dx.doi.org/10.1016/j.envres.2011.07.004
Relation:	Environmental Research Volume 111, Issue 8, November 2011, Pages 1185–1191
Appears in Collections:	[口腔醫學研究所] 期刊論文

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