Gold nanoparticles induce surface morphological transformation in polyurethane and affect the cellular response.

doi:10.1021/bm700471k

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 口腔醫學研究所 > 期刊論文 > Item 310902500/15645

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题名:	Gold nanoparticles induce surface morphological transformation in polyurethane and affect the cellular response.
作者:	Hsu, SH;Tang, CM;Tseng, HJ.
贡献者:	中山醫大口腔科學研究所
日期:	2007-12-29
上传时间:	2016-08-05T04:11:30Z (UTC)
摘要:	Nanocomposites from a hexamethylene diisocyanate (HDI)-based polyester-type waterborne polyurethane (PU) containing different amounts (17.4-174 ppm) of gold (Au) nanoparticles (approximately 5 nm) were prepared. The microstructure and physiochemical properties of the nanocomposites were characterized. The cell attachment and proliferation, platelet activation, and bacterial adhesion on the nanocomposites were evaluated. Gold nanoparticles in small amounts induced significant changes in surface morphology and domain structures, from hard segment lamellae to soft segment micelles. These changes resembled the morphological transformation among different mesophases occurred in diblock copolymers. Better cellular proliferation, lower platelet activation, and reduced bacterial adhesion were demonstrated for the PU nanocomposite with 43.5 or 65 ppm of Au than the pure PU or the nanocomposite containing a different amount of Au. The different cellular response on PU-Au nanocomposites was attributed to the extensively modified surface morphology and phase separation in the presence of a small amount of Au nanoparticles.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/15645
關聯:	Biomacromolecules. 2008 Jan;9(1):241-8
显示于类别:	[口腔醫學研究所] 期刊論文

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