Association between interleukin-18 polymorphisms and hepatocellular carcinoma occurrence and clinical progression

doi:10.7150/ijms.15853

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學研究所 > 期刊論文 > Item 310902500/15625

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/15625

Title:	Association between interleukin-18 polymorphisms and hepatocellular carcinoma occurrence and clinical progression
Authors:	Lau, H.-K.;Hsieh, M.-J.;Yang, S.-F.;Wang, H.-L.;Kuo, W.-H.;Lee, H.-L.;Yeh, C.-B.
Contributors:	醫學研究所
Keywords:	Hepatitis B virus;Hepatocellular carcinoma;Interleukin-18
Date:	2016-07-05
Issue Date:	2016-08-04T04:34:12Z (UTC)
Publisher:	Ivyspring International Publisher
ISSN:	14491907
Abstract:	We investigated the association between interleukin-18 (IL-18) polymorphisms and the susceptibility and clinicopathological state of hepatocellular carcinoma (HCC). In total, 901 participants, including 559 healthy controls and 342 patients with HCC, were recruited. The allelic discrimination of −607A/C (rs1946518) and −137G/C (rs187238) polymorphisms of IL-18 was assessed through real-time polymerase chain reaction by performing the TaqMan assay. The IL-18 −137G/C polymorphism but not the −607A/C polymorphism showed a significant association with the risk of HCC. Participants carrying the IL-18 −137 polymorphism with heterozygous G/C and homozygous CC genotypes showed a 1.987-fold increase (95% CI = 1.301–3.032; p = 0.001) in the risk of HCC compared with those homozygous for wild-type G/G. The 342 patients with HCC carrying the IL-18 −137G/C polymorphism were positive for hepatitis B virus (HBV) infection with an adjusted odds ratio of 1.668. Moreover, the 142 HBV positive patients with HCC and the IL-18 −137 polymorphism were positive for at least one C genotype and showed significant vascular invasion (p = 0.018). Furthermore, the level of α-fetoprotein was high in the patients carrying the IL-18 −137 polymorphism with GC+CC alleles (p = 0.011). In conclusion, the IL-18 −137G/C polymorphism with a GC+CC genotype could be a factor that increases the risk of HCC. Furthermore, the correlation between the IL-18 −137G/C polymorphism and HCC-related HBV infection is a risk factor for vascular invasion and has a synergistic effect that can further enhance HCC prognosis. © 2016, Ivyspring International Publisher. All rights reserved.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/15625 http://dx.doi.org/10.7150/ijms.15853
Relation:	International Journal of Medical Sciences Volume 13, Issue 7, 5 July 2016, Pages 556-561
Appears in Collections:	[醫學研究所] 期刊論文

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