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https://ir.csmu.edu.tw:8080/ir/handle/310902500/15617
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| Title: | Statin treatment is associated with a negative correlation between NT-proBNP and insulin resistance in patients without history of heart failure |
| Authors: | Wang, J.-S.
Lee, C.-L.
Lee, W.-J.
Lee, I.-T.
Lin, S.-Y.
Lee, W.-L.
Liang, K.-W.
Sheu, W.H.-H. |
| Contributors: | 醫學研究所 |
| Keywords: | Insulin resistance;NT-proBNP;Statin |
| Date: | 2016-08-01 |
| Issue Date: | 2016-08-04T03:59:20Z (UTC)
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| Publisher: | Elsevier |
| ISSN: | 00098981 |
| Abstract: | Background: We investigated the effect of statin treatment on the relationship between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and insulin resistance in patients without history of heart failure. Methods: Patients without history of heart failure and diabetes were recruited to undergo an oral glucose tolerance test. Blood samples were collected for measurements of NT-proBNP, glucose, and insulin. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR). Linear mixed model analysis was used to examine the correlation between NT-proBNP and HOMA-IR. Results: A total of 219 patients (mean age 61.1 ± 11.8 y, median NT-proBNP 64.3 [32.1-154.5] pg/ml) were analyzed. Overall, NT-proBNP was negatively correlated with HOMA-IR after an adjustment for confounders (β coefficient -. 0.335, 95% CI [- 0.516, - 0.153], p = 0.001). This correlation was significant in patients on statin treatment (n = 91, β coefficient - 0.558, 95% CI [-. 0.802, - 0.312], p < 0.001), but was insignificant in patients not on statin treatment (n = 128, β coefficient - 0.147, 95% CI [- 0.412, 0.118], p = 0.274, p for interaction = 0.040). Conclusions: Statin treatment is associated with a negative correlation between NT-proBNP and insulin resistance in patients without history of heart failure. Our findings suggest that NT-proBNP may be related to insulin resistance associated with statin treatment. © 2016 Elsevier B.V.. |
| URI: | https://ir.csmu.edu.tw:8080/ir/handle/310902500/15617
http://dx.doi.org/10.1016/j.cca.2016.05.019 |
| Relation: | Clinica Chimica Acta Volume 459, 1 August 2016, Pages 84-88 |
| Appears in Collections: | [醫學研究所] 期刊論文
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