Differential effects of grape juice on gastric emptying and renal function from cisplatin-induced acute adverse toxicity

doi:10.1177/0960327115607079

中山醫學大學機構典藏 CSMUIR > 健康管理學院 > 營養學系暨碩士班 > 期刊論文 > Item 310902500/15606

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/15606

Title:	Differential effects of grape juice on gastric emptying and renal function from cisplatin-induced acute adverse toxicity
Authors:	Ko, J.-L. Tsai, C.-H. Liu, T.-C. Lin, M.-Y. Lin, H.-L. Ou, C.-C.
Contributors:	營養系
Keywords:	cisplatin;gastric emptying;grape juice;Nephrotoxicity;oxidative stress
Date:	2016-08-01
Issue Date:	2016-08-04T03:32:06Z (UTC)
Publisher:	SAGE Publications Ltd
ISSN:	0960-3271
Abstract:	Grape skin and seeds contain large amounts of phytochemicals such as polyphenols, resveratrol, and proanthocyanidins, which possess antioxidant activities. Cisplatin is widely used in the treatment of cancer. High doses of cisplatin have also been known to produce acute adverse effects. The aim of this study was to investigate the protective effects of antioxidant properties of whole grape juice (with skin and seeds) on cisplatin-induced acute gastrointestinal tract disorders and nephrotoxicity in Wistar rats. Gastric emptying is significantly increased in whole grape juice-pretreated rats when compared to cisplatin treatment alone. The expression of ghrelin mRNA of stomach is increased in rats with whole grape juice. However, pretreatment with whole grape juice did not reduce renal function markers in acute renal toxicity. No significant changes were recorded in the oxidative stress/antioxidant status parameters of any study group. In contrast, pretreatment with whole grape juice slightly improved tubular cell vacuolization, tubular dilatation, and cast formation in renal tubules. These results show that consumption of whole grape juice induces somewhat beneficial effects in preventing cisplatin-mediated dyspepsia but does not offer protection against cisplatin-induced acute renal toxicity. © The Author(s) 2015.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/15606 http://dx.doi.org/10.1177/0960327115607079
Relation:	Human and Experimental Toxicology Volume 35, Issue 8, 1 August 2016, Pages 808-817
Appears in Collections:	[營養學系暨碩士班] 期刊論文

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