Physical characteristics, antimicrobial and odontogenesis potentials of calcium silicate cement containing hinokitiol

doi:10.1016/j.msec.2016.04.016

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/15605

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/15605

Title:	Physical characteristics, antimicrobial and odontogenesis potentials of calcium silicate cement containing hinokitiol
Authors:	Huang, M.-H. Shen, Y.-F. Hsu, T.-T. Huang, T.-H. Shie, M.-Y.
Contributors:	醫學研究所
Keywords:	Anti-bacterial;Anti-inflammatory;Hinokitiol;Human dental pulp cell;Odontogenic
Date:	2016-08-01
Issue Date:	2016-08-04T03:24:10Z (UTC)
Publisher:	Elsevier Ltd
ISSN:	0928-4931
Abstract:	Hinokitiol is a natural material and it has antibacterial and anti-inflammatory effects. The purpose of this study was to evaluate the material characterization, cell viability, antibacterial and anti-inflammatory abilities of the hinokitiol-modified calcium silicate (CS) cement as a root end filling material. The setting times, diametral tensile strength (DTS) values and XRD patterns of CS cements with 0-10 mM hinokitiol were examined. Then, the antibacterial effect and the expression levels of cyclooxygenase 2 (COX-2) and interleukin-1 (IL-1) of the hinokitiol-modified CS cements were evaluated. Furthermore, the cytocompatibility, the expression levels of the markers of odontoblastic differentiation, mineralized nodule formation and calcium deposition of human dental pulp cells (hDPCs) cultured on hinokitiol-modified CS cements were determined. The hinokitiol-modified CS cements had better antibacterial and anti-inflammatory abilities and cytocompatibility than non-modified CS cements. Otherwise, the hinokitiol-modified CS cements had suitable setting times and better odontoblastic potential of hDPCs. Previous report pointed out that the root-end filling materials may induce inflammatory cytokines reaction. In our study, hinokitiol-modified CS cements not only inhibited the expression level of inflammatory cytokines, but also had better cytocompatibility, antimicrobial properties and active ability of odontoblastic differentiation of hDPCs. Therefore, the hinokitiol-modified CS cement may be a potential root end filling material for clinic. © 2016 Elsevier B.V.All rights reserved.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/15605 http://dx.doi.org/10.1016/j.msec.2016.04.016
Relation:	Materials Science and Engineering C Volume 65, 1 August 2016, Pages 1-8
Appears in Collections:	[牙醫學系暨碩士班] 期刊論文

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