| Abstract: | 良性前列腺肥大患者前列腺體積與臨床症狀參數的
相關性研究
目的: 對於有下泌尿道症狀並診斷為良性前列腺肥大(Benign Prostatic Hyperplasia；BPH)之患者，探討前列腺體積參數與臨床症狀參數之間的相關性分析。
材料與方法: 自2002年3月至2002年8月，共 54名有BPH臨床症狀初診患者參與此項研究。首先利用經直腸超音波(Transrectal Ultrasound；TRUS)測量出前列腺總體積(Prostate Volume；PV) 、 移形區體積(Transition Zone Volume；TZV) ，並計算 出移形區指數(Transition Zone Index；TZI)之數據 ； 並且與年齡(Age)、美國泌尿科醫學會前列腺症狀評分(American Urologic Association Symptom Index；AUASI)、(Maximal Flow Rate；Qmax)進行相關性研究之統計分析。
結果: 一：年齡與前列腺體積、前列腺移形區體積、前列腺移形區指數沒有相關（r=0.004, 0.165, 0.263 ；P>0.05）。年齡與AUASI與Qmax 亦無相關（r=0.014, -0.108 ； P>0.05）。
二：AUASI與前列腺移形區指數有相關（r=0.294 ；P<0.05），與前列腺總體積、前列腺移形區體積沒有相關（r=0.248, 0.268 ；P>0.05） 。
三：Qmax與前列腺總體積有相關（r= -0.320, P<0.05）；與前列腺移形區體積、前列腺移形區指數有顯著相關（r= -0.440, P<0.01 ；r=-0.414 , P<0.01）。
結論: 本研究結果顯示，TZI和AUASI之間有相關（P<0.05），並且與患者的Qmax也有顯著相關（P<0.01）。而年齡與體積參數和症狀參數間則無相關性。因此對於良性前列腺肥大患者臨床阻塞症狀之評估，TZI與Qmax可以提供良好的資訊；尤其當病患要接受手術治療時，TZI與AUASI更可以當作一個很好的指標。雖然有許多研究與此結論不同，但原因應該是選擇研究對象與研究設計的不同。綜合以上結論，對於良性前列腺肥大患者之探討，雖然仍存有許多的爭議；但在描述良性前列腺肥大患者臨床特徵上，TZI是一個良好的特異性指標，值得我們更進一步的研究。
The Correlation Between Prostate Volume and Clinical Measurements in Benign Prostatic Hyperplasia Patients
Purpose: To elucidate the correlation of prostate volume with clinical measurements in Benign Prostatic Hyperplasia (BPH) patients
with lower urinary tract symptoms.
Material and methods: From March 2002 to August 2002, 54 patients with symptomatic BPH were enrolled in this study. They all underwent transrectal ultrasound (TRUS) for Prostate Volume (PV) , Transition Zone volume (TZV) and Transition Zone Index (TZI) measurment, to elucidate the correlation of volume measurements with Age, American Urological Association Symptom Index (AUASI) and Maximal Flow Rate (Qmax) for statistical analysis.
Results : 1.The correlation of Age with PV and TZV and TZI were not significant (r=0.004, 0.165, o.263 ; P>0.05). The correlation of Age with AUASI and Qmax were not significant (r=0.014, -0.018 ; P>0.05).
2.The correlation of AUASI with TZI were significant (r=0.294 ; P <0.05). The correlation of AUASI with PV and TZV were not significant (r=0.248, 0.268 ; P>0.05).
3. The correlation of Qmax with PV , TZV and TZI were significant (r= -0.320, P<0.05 ; r= -0.440, P<0.01; r= -0.414, P<0.01)
Conclusion:The results of these studies demonstrate that the correlation of TZI with AUASI were statistically significant (P<0.05), and with Qmax were statistically significant (P<0.01). The correlation of Age with prostate volume and clinical measurements were not statistically significant(P>0.05). For the evaluation of BPH patients’ clinical obstructive symptoms, TZI and Qmax provided important information ; especially for those patients who needed further surgery treatment, TZI and AUASI were a good index .These results were different in contrast with previous studies and the reasons might be due to the fact that the study populations and designs were different. The conclusion is that there are many unsettled issues in BPH patients ; but for the elucidation of BPH clinical characters , TZI was a good specific index .Thus further study and research are indicated. |
