中山醫學大學機構典藏 CSMUIR:Item 310902500/12031
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    题名: Multidrug Resistance 1 Gene Variants, Pesticide Exposure, and Increased Risk of DNA Damage
    作者: Chun-Chieh Chen;Chun-Huang Huang;Man-Tzu Marcie Wu;hia-Hsuan Chou;Chia-Chen Huang;Tzu-Yen Tseng;Fang-Yu Chang;Ying-Ti Li;Chun-Cheng Tsai;Tsung-Shing Wang;Ruey-Hong Wong
    贡献者: 中山醫學大學
    日期: 2014
    上传时间: 2015-08-12T08:52:51Z (UTC)
    摘要: The P-glycoprotein, encoded by the multidrug resistance (MDR)1 gene, extrudes fat-soluble compounds to the extracellular environment. However, the DNA damage of pesticides in subjects with genetic variation in MDR1 has not been investigated. In this study, the comet assay was applied to examine the extent of DNA damage in the peripheral blood of 195 fruit growers who had been exposed to pesticides and 141 unexposed controls. The MDR1 polymorphisms were identified. Questionnaires were administered to obtain demographic data and occupational history. Results showed subjects experiencing high (2.14 m/cell, ) or low pesticide exposure (2.18 m/cell, ) had a significantly greater DNA tail moment than controls (1.28 m/cell). Compared to the MDR1 T-129C (rs3213619) TC/CC carriers, the TT carriers had increased DNA tail moment in controls (1.30 versus 1.12 m/cell, ). Similar results were observed in the high and low pesticide-exposed groups. Combined analysis revealed that pesticide-exposed fruit growers with MDR1 -129 TT genotype had the greatest DNA damage in the subjects with the combinations of pesticide exposure and MDR1 -129 genotypes. In conclusion, pesticide exposed individuals with susceptible MDR1 -129 genotypes may experience increased risk of DNA damage.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/12031
    關聯: BioMed Research International Volume 2014 (2014),9 pages
    显示于类别:[公共衛生學系暨碩士班] 期刊論文

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