中山醫學大學機構典藏 CSMUIR:Item 310902500/11916
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    题名: Trace elements, oxidative stress and glycemic control in young people with type 1 diabetes mellitus.
    作者: Lin CC;Huang HH;Hu CW;Chen BH;Chong IW;Chao YY;Huang YL
    贡献者: 中山醫學大學
    关键词: 8-Hydroxy-2′-deoxyguanosine;Copper;Malondialdehyde;Type 1 diabetes mellitus;Zinc
    日期: 2014-01
    上传时间: 2015-08-04T05:46:27Z (UTC)
    摘要: Trace elements and oxidative stress are associated with glycemic control and diabetic complications in type 1 diabetes mellitus. In this study, we analyzed the levels of serum copper, zinc, superoxide dismutase (SOD) activity, and malondialdehyde (MDA) and urinary MDA and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in 33 type 1 diabetic patients with optimal and suboptimal glycemic control (HbA1C<9.0%) and 40 patients with poor glycemic control (HbA1C≥9%) and 27 age- and sex-matched non-diabetic controls to evaluate the differences between these markers in different glycemic control states. Diabetic patients, especially poor-glycemic-control subjects (HbA1C≥9%), exhibited significantly lower levels of serum zinc and increased levels of serum copper (and, therefore, increased serum copper-to-zinc ratios), serum SOD, blood MDA, and urinary MDA and 8-OHdG, relative to non-diabetic subjects. Furthermore, significant correlations existed in these patients between the serum copper, serum copper-to-zinc ratio, and urinary MDA (all p<0.001) and the levels of urinary 8-OHdG (p=0.007) and HbA1C. Our results suggest that high serum copper levels and oxidative stress correlate with glycemic control. Therefore, strict glycemic control, decreased oxidative stress, and a lower copper concentration might prevent diabetic complications in patients with type 1 diabetes mellitus.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/11916
    關聯: J Trace Elem Med Biol. 2014 Jan;28(1):18-22
    显示于类别:[公共衛生學系暨碩士班] 期刊論文

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